Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency.

Autor:	Guevara-Aguirre J; College of Medicine, Universidad San Francisco de Quito, Quito, Ecuador; Instituto de Endocrinología IEMYR, Quito, Ecuador; Maastricht University, Maastricht, the Netherlands. Electronic address: vlongo@usc.edu., Mishra A; Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA; Department of Life Sciences, GITAM (Deemed to be University), Bengaluru, India., Canepa M; Cardiovascular Unit, Ospedale Policlinico San Martino IRCCS, Genova, Italy; Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy., Guevara C; College of Medicine, Universidad San Francisco de Quito, Quito, Ecuador; Instituto de Endocrinología IEMYR, Quito, Ecuador., Villacres Á; College of Medicine, Universidad San Francisco de Quito, Quito, Ecuador., Guevara A; Instituto de Endocrinología IEMYR, Quito, Ecuador., Peña G; College of Medicine, Universidad San Francisco de Quito, Quito, Ecuador., Lescano D; College of Medicine, Universidad San Francisco de Quito, Quito, Ecuador., Kopchick JJ; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine and Edison Biotechnology Institute, Ohio University, Athens, OH, USA., Balasubramanian P; Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA., Longo VD; Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA; IFOM, AIRC Institute of Molecular Oncology, Milan, Italy. Electronic address: vlongo@usc.edu.
Jazyk:	angličtina
Zdroj:	Med (New York, N.Y.) [Med] 2024 Jul 12; Vol. 5 (7), pp. 816-825.e4. Date of Electronic Publication: 2024 Apr 26.
DOI:	10.1016/j.medj.2024.03.022
Abstrakt:	Background: Human subjects with generalized growth hormone (GH) insensitivity due to GH receptor deficiency (GHRD)/Laron syndrome display a very low incidence of insulin resistance, diabetes, and cancer, as well as delayed age-related cognitive decline. However, the risk of cardiovascular disease (CVD) in these subjects is poorly understood. Here, we have assessed cardiovascular function, damage, and risk factors in GHRD subjects and their relatives. Methods: We measured markers of CVD in two phases: one in a cohort of 30 individuals (GHRD = 16, control relatives = 14) brought to USC (in Los Angeles, CA) and one in a cohort including additional individuals examined in Ecuador (where the subjects live) for a total of 44 individuals (GHRD = 21, control relatives = 23). Data were collected on GHRD and control groups living in similar geographical locations and sharing comparable environmental and socio-economic circumstances. Results: Compared to controls, GHRD subjects displayed lower serum glucose, insulin, blood pressure, smaller cardiac dimensions, similar pulse wave velocity, lower carotid artery intima-media thickness, lower creatinine, and a non-significant but major reduction in the portion of subjects with carotid atherosclerotic plaques (7% GHRDs vs. 36%, Controls p = 0.1333) despite elevated low-density lipoprotein cholesterol levels. Conclusion: The current study indicates that individuals with GHRD have normal or improved levels of cardiovascular disease risk factors as compared to their relatives. Funding: This study was funded in part by NIH/NIA grant P01 AG034906 to V.D.L. Competing Interests: Declaration of interests V.D.L. has equity interest in L-Nutra, which develops and sells medical food for the prevention and treatment of diseases. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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