| Autor: |
Zalyalova ZA; Kazan State Medical University, Kazan, Russia.; Republican Consultative and Diagnostic Center for Extrapyramidal Pathology and Botulinum Therapy, Kazan, Russia., Katunina EA; Pirogov Russian National Research Medical University, Moscow, Russia.; Federal Center for Brain and Neurotechnology, Moscow, Russia., Pokhabov DV; Center for Innovative Neurology, Extrapyramidal Diseases and Botulinum Therapy, Krasnoyarsk, Russia.; Voino-Yasnevetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia., Munasipova SE; Kazan State Medical University, Kazan, Russia.; Republican Consultative and Diagnostic Center for Extrapyramidal Pathology and Botulinum Therapy, Kazan, Russia., Ermakova MM; Kazan State Medical University, Kazan, Russia. |
| Abstrakt: |
The article is of a review nature and is devoted to tremor, one of the maladaptive and difficult-to-treat symptoms of Parkinson's disease (PD). Along with the classic rest tremor, patients with PD may experience tremor of other modalities: postural tremor, kinetic tremor, which reflects a multimodal mechanism of tremor formation involving multiple neurotransmitter systems. The unpredictable response to therapeutic options, the ambiguous response to levodopa, also reflects the role of multiple underlying pathophysiological processes. Among the drug methods of tremor correction, preference is given to dopamine receptor agonists - due to the spectrum of their pharmaceutical action, high efficiency in relation to all leading motor and a number of non-motor manifestations. The evidence for advanced neurosurgical, non-invasive modalities is mixed, and there are insufficient comparative studies to assess their efficacy in patients with tremor-dominant forms of PD. |
