Enhancing X-Ray Sensitization with Multifunctional Nanoparticles.

Autor: Liu J; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China., Wu J; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China., Chen T; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China., Yang B; Department of Orthopedics, Shaodong People's Hospital, Shaoyang, Hunan Province, 422800, China., Liu X; Department of Neurology, Shaodong People's Hospital, Shaoyang, Hunan Province, 422800, China., Xi J; Department of Nephrology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, Hunan Province, 415000, China., Zhang Z; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, 119276, Singapore.; Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore, 117544, Singapore., Gao Y; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China., Li Z; Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China.; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Aug; Vol. 20 (35), pp. e2400954. Date of Electronic Publication: 2024 Apr 26.
DOI: 10.1002/smll.202400954
Abstrakt: In the progression of X-ray-based radiotherapy for the treatment of cancer, the incorporation of nanoparticles (NPs) has a transformative impact. This study investigates the potential of NPs, particularly those comprised of high atomic number elements, as radiosensitizers. This aims to optimize localized radiation doses within tumors, thereby maximizing therapeutic efficacy while preserving surrounding tissues. The multifaceted applications of NPs in radiotherapy encompass collaborative interactions with chemotherapeutic, immunotherapeutic, and targeted pharmaceuticals, along with contributions to photodynamic/photothermal therapy, imaging enhancement, and the integration of artificial intelligence technology. Despite promising preclinical outcomes, the paper acknowledges challenges in the clinical translation of these findings. The conclusion maintains an optimistic stance, emphasizing ongoing trials and technological advancements that bolster personalized treatment approaches. The paper advocates for continuous research and clinical validation, envisioning the integration of NPs as a revolutionary paradigm in cancer therapy, ultimately enhancing patient outcomes.
(© 2024 The Authors. Small published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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