| Autor: |
Šimičić P; Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Vinogradska cesta 29, 10 000 Zagreb, Croatia., Batović M; Department of Clinical Microbiology and Hospital Infections, Dubrava University Hospital, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia., Stojanović Marković A; Department of Immunological and Molecular Diagnostics, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', Mirogojska 8, 10 000 Zagreb, Croatia., Židovec-Lepej S; Department of Immunological and Molecular Diagnostics, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', Mirogojska 8, 10 000 Zagreb, Croatia. |
| Jazyk: |
angličtina |
| Zdroj: |
Viruses [Viruses] 2024 Apr 04; Vol. 16 (4). Date of Electronic Publication: 2024 Apr 04. |
| DOI: |
10.3390/v16040564 |
| Abstrakt: |
The disruption of antiviral sensors and the evasion of immune defences by various tactics are hallmarks of EBV infection. One of the EBV latent gene products, LMP1, was shown to induce the activation of signalling pathways, such as NF-κB, MAPK (JNK, ERK1/2, p38), JAK/STAT and PI3K/Akt, via three subdomains of its C-terminal domain, regulating the expression of several cytokines responsible for modulation of the immune response and therefore promoting viral persistence. The aim of this review is to summarise the current knowledge on the EBV-mediated induction of immunomodulatory molecules by the activation of signal transduction pathways with a particular focus on LMP1-mediated mechanisms. A more detailed understanding of the cytokine biology molecular landscape in EBV infections could contribute to the more complete understanding of diseases associated with this virus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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