| Autor: |
Kuzmina NS; Department of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia., Fedotova EA; Department of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia., Jankovic P; Department of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia., Gribova GP; Department of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia., Nyuchev AV; Department of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia., Fedorov AY; Department of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia., Otvagin VF; Department of Organic Chemistry, Lobachevsky State University of Nizhny Novgorod, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia. |
| Abstrakt: |
Over the past few decades, photodynamic therapy (PDT) has evolved as a minimally invasive treatment modality offering precise control over cancer and various other diseases. To address inherent challenges associated with PDT, researchers have been exploring two promising avenues: the development of intelligent photosensitizers activated through light-induced energy transfers, charges, or electron transfers, and the disruption of photosensitive bonds. Moreover, there is a growing emphasis on the bioorthogonal delivery or activation of photosensitizers within tumors, enabling targeted deployment and activation of these intelligent photosensitive systems in specific tissues, thus achieving highly precise PDT. This concise review highlights advancements made over the last decade in the realm of light-activated or bioorthogonal photosensitizers, comparing their efficacy and shaping future directions in the advancement of photodynamic therapy. |
