| Autor: |
Ding M; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China., Li B; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China., Chen H; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China., Ross RP; International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214122, China.; APC Microbiome Ireland, University College Cork, T12 R229 Cork, Ireland., Stanton C; International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214122, China.; APC Microbiome Ireland, University College Cork, T12 R229 Cork, Ireland.; Teagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Cork, Ireland., Zhao J; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China., Chen W; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China., Yang B; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214122, China. |
| Abstrakt: |
Throughout infancy, IgA is crucial for maintaining gut mucosal immunity. This study aims to determine whether supplementing newborn mice with eight different strains of Bifidobacterium longum subsp. infantis might regulate their IgA levels. The strains were gavaged to BALB/C female ( n = 8) and male ( n = 8) dams at 1-3 weeks old. Eight strains of B. longum subsp. infantis had strain-specific effects in the regulation of intestinal mucosal barriers. B6MNI, I4MI, and I10TI can increase the colonic IgA level in females and males. I8TI can increase the colonic IgA level in males. B6MNI was also able to significantly increase the colonic sIgA level in females. B6MNI, I4MI, I8TI, and I10TI regulated colonic and Peyer's patch IgA synthesis genes but had no significant effect on IgA synthesis pathway genes in the jejunum and ileum. Moreover, the variety of sIgA-coated bacteria in male mice was changed by I4MI, I5TI, I8TI, and B6MNI. These strains also can decrease the relative abundance of Escherichia coli . These results indicate that B. longum subsp. infantis can promote IgA levels but show strain specificity. Different dietary habits with different strains of Bifidobacterium may have varying effects on IgA levels when supplemented in early infancy. |
