| Autor: |
Neves MM; Biotechnology in Experimental Models Laboratory-LABME, Federal University of Uberlândia, Uberlândia 38405-330, MG, Brazil., Guerra RF; Biotechnology in Experimental Models Laboratory-LABME, Federal University of Uberlândia, Uberlândia 38405-330, MG, Brazil.; Rodents Animal Facilities Complex, Federal University of Uberlandia, Uberlândia 38400-902, MG, Brazil., de Lima IL; Biotechnology in Experimental Models Laboratory-LABME, Federal University of Uberlândia, Uberlândia 38405-330, MG, Brazil., Arrais TS; Biotechnology in Experimental Models Laboratory-LABME, Federal University of Uberlândia, Uberlândia 38405-330, MG, Brazil., Guevara-Vega M; Innovation Center in Salivary Diagnostic and Nanotheranostics, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlândia 38408-100, MG, Brazil., Ferreira FB; Biotechnology in Experimental Models Laboratory-LABME, Federal University of Uberlândia, Uberlândia 38405-330, MG, Brazil., Rosa RB; Rodents Animal Facilities Complex, Federal University of Uberlandia, Uberlândia 38400-902, MG, Brazil., Vieira MS; Faculty of Medicine, Maria Ranulfa Institute, Av. Vasconselos Costa 321, Uberlândia 38400-448, MG, Brazil., Fonseca BB; School of Veterinary Medicine, Federal University of Uberlandia, Uberlândia 30402-018, MG, Brazil., Sabino da Silva R; Innovation Center in Salivary Diagnostic and Nanotheranostics, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlândia 38408-100, MG, Brazil., Silva MVD; Biotechnology in Experimental Models Laboratory-LABME, Federal University of Uberlândia, Uberlândia 38405-330, MG, Brazil.; Rodents Animal Facilities Complex, Federal University of Uberlandia, Uberlândia 38400-902, MG, Brazil. |
| Abstrakt: |
Currently, there is a wide application in the literature of the use of the Fourier Transform Infrared Spectroscopy (FTIR) technique. This basic tool has also proven to be efficient for detecting molecules associated with hosts and pathogens in infections, as well as other molecules present in humans and animals' biological samples. However, there is a crisis in science data reproducibility. This crisis can also be observed in data from experimental animal models (EAMs). When it comes to rodents, a major challenge is to carry out sanitary monitoring, which is currently expensive and requires a large volume of biological samples, generating ethical, legal, and psychological conflicts for professionals and researchers. We carried out a survey of data from the relevant literature on the use of this technique in different diagnostic protocols and combined the data with the aim of presenting the technique as a promising tool for use in EAM. Since FTIR can detect molecules associated with different diseases and has advantages such as the low volume of samples required, low cost, sustainability, and provides diagnostic tests with high specificity and sensitivity, we believe that the technique is highly promising for the sanitary and stress and the detection of molecules of interest of infectious or non-infectious origin. |
