| Autor: |
Leung M; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Steinman J; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Li D; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Lor A; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Gruesen A; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Sadah A; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., van Kuijk FJ; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Montezuma SR; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Kondkar AA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 12271, Saudi Arabia., Radhakrishnan R; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Lobo GP; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA. |
| Abstrakt: |
In this review, we outline our current understanding of the mechanisms involved in the absorption, storage, and transport of dietary vitamin A to the eye, and the trafficking of rhodopsin protein to the photoreceptor outer segments, which encompasses the logistical backbone required for photoreceptor cell function. Two key mechanisms of this process are emphasized in this manuscript: ocular and systemic vitamin A membrane transporters, and rhodopsin transporters. Understanding the complementary mechanisms responsible for the generation and proper transport of the retinylidene protein to the photoreceptor outer segment will eventually shed light on the importance of genes encoded by these proteins, and their relationship on normal visual function and in the pathophysiology of retinal degenerative diseases. |
