The Potential Role of Presepsin in Predicting Severe Infection in Patients with Diabetic Foot Ulcers.

Autor: Ha EY; Department of Internal Medicine, Yeungnam University Medical Center, Daegu 42415, Republic of Korea., Park IR; Department of Internal Medicine, Yeungnam University Medical Center, Daegu 42415, Republic of Korea., Chung SM; Department of Internal Medicine, Yeungnam University Medical Center, Daegu 42415, Republic of Korea., Roh YN; Department of Surgery, Yeungnam University Medical Center, Daegu 42415, Republic of Korea., Park CH; Department of Orthopedic Surgery, Yeungnam University Medical Center, Daegu 42415, Republic of Korea., Kim TG; Department of Plastic Surgery, Yeungnam University Medical Center, Daegu 42415, Republic of Korea., Kim W; Department of Internal Medicine, Yeungnam University Medical Center, Daegu 42415, Republic of Korea., Moon JS; Department of Internal Medicine, Yeungnam University Medical Center, Daegu 42415, Republic of Korea.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Apr 17; Vol. 13 (8). Date of Electronic Publication: 2024 Apr 17.
DOI: 10.3390/jcm13082311
Abstrakt: Background/Objectives : Diabetic foot ulcers are one of the complications in patients with diabetes, which can be caused by infection, neuropathy, and blood vessel disorder. Among them, infection is the most common cause, and if it becomes worse, amputation may be necessary. So, it is important to detect and treat infections early, and determining indicators that can confirm infection is also important. Known infection markers include white blood cells (WBCs), the erythrocyte sediment rate (ESR), C-reactive protein (CRP), and procalcitonin, but they are not specific to diabetic foot ulcers. Presepsin, also known as soluble CD14, is known to be an early indicator of sepsis. Recent studies have reported that presepsin can be used as an early indicator of infection. This study investigated whether presepsin could be used as an early marker of severe infection in patients with diabetic foot ulcers. Methods: We retrospectively studied 73 patients who were treated for diabetic foot ulcerations from January 2021 to June 2023 at Yeungnam University Hospital. Results: Out of a total of 73 patients, 46 patients underwent amputations with severe infections, and the WBC level, ESR, and CRP, procalcitonin, and presepsin levels were significantly higher in the group of patients who underwent amputations. The cutoff of presepsin, which can predict serious infections that need amputation, was 675 ng/mL. A regression analysis confirmed that presepsin, HbA1c, and osteomyelitis significantly increased the risk of severe infections requiring amputation. Conclusions: Presepsin will be available as an early predictor of patients with severe infections requiring amputations for diabetic foot ulcerations.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje