| Autor: |
Nunes FC; Postgraduate Programme in Materials Science and Engineering, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, Brazil., Santos SIP; Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Pirassununga 13635-900, SP, Brazil., Colnago LA; Brazilian Agricultural Research Corporation, EMBRAPA Instrumentation, Rua Quinze de Novembro, 1500/1501, São Carlos 13561-206, SP, Brazil., Hammer P; Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-900, SP, Brazil., Ferreira JA; Fundação Hermínio Ometto, Fundação Hermínio Ometto (FHO), Av. Dr. Maximiliano Baruto, 500, Araras 13607-339, SP, Brazil., Ambrósio CE; Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Pirassununga 13635-900, SP, Brazil., Pallone EMJA; Postgraduate Programme in Materials Science and Engineering, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, Brazil.; Department of Biosystem Engineering, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Pirassununga 13635-900, SP, Brazil. |
| Abstrakt: |
This study investigates the profound impact of the ZrO 2 inclusion volume on the characteristics of Al 2 O 3 /ZrO 2 nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15 vol% ZrO 2 , subjecting them to chemical surface treatment for enhanced calcium phosphate deposition sites. Biomimetic coating with Sr-enriched simulated body fluid (SBF) further enhanced the bioactivity of nanocomposites. While the ZrO 2 concentration heightened the oxygen availability on nanocomposite surfaces, the quantity of Sr-containing phosphate was comparatively less influenced than the formation of calcium phosphate phases. Notably, the coated nanocomposites exhibited a high cell viability and no toxicity, signifying their potential in bone tissue engineering. Overall, these findings contribute to the development of regenerative biomaterials, holding promise for enhancing bone regeneration therapies. |
