A Perspective Review: Analyzing Collagen Alterations in Ovarian Cancer by High-Resolution Optical Microscopy.

Autor: Gant KL; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53706, USA.; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA., Patankar MS; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53706, USA.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53706, USA., Campagnola PJ; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Apr 19; Vol. 16 (8). Date of Electronic Publication: 2024 Apr 19.
DOI: 10.3390/cancers16081560
Abstrakt: High-grade serous ovarian cancer (HGSOC) is the predominant subtype of ovarian cancer (OC), occurring in more than 80% of patients diagnosed with this malignancy. Histological and genetic analysis have confirmed the secretory epithelial of the fallopian tube (FT) as a major site of origin of HGSOC. Although there have been significant strides in our understanding of this disease, early stage detection and diagnosis are still rare. Current clinical imaging modalities lack the ability to detect early stage pathogenesis in the fallopian tubes and the ovaries. However, there are several microscopic imaging techniques used to analyze the structural modifications in the extracellular matrix (ECM) protein collagen in ex vivo FT and ovarian tissues that potentially can be modified to fit the clinical setting. In this perspective, we evaluate and compare the myriad of optical tools available to visualize these alterations and the invaluable insights these data provide on HGSOC initiation. We also discuss the clinical implications of these findings and how these data may help novel tools for early diagnosis of HGSOC.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje