Krill Oil and Its Bioactive Components as a Potential Therapy for Inflammatory Bowel Disease: Insights from In Vivo and In Vitro Studies.

Autor: Liu Y; Institute for Health & Sport, Victoria University, Melbourne, VIC 3021, Australia., Robinson AM; Institute for Health & Sport, Victoria University, Melbourne, VIC 3021, Australia.; School of Rural Health, La Trobe University, Melbourne, VIC 3010, Australia.; Department of Medicine Western Health, The University of Melbourne, Melbourne, VIC 3010, Australia., Su XQ; Institute for Health & Sport, Victoria University, Melbourne, VIC 3021, Australia., Nurgali K; Institute for Health & Sport, Victoria University, Melbourne, VIC 3021, Australia.; Department of Medicine Western Health, The University of Melbourne, Melbourne, VIC 3010, Australia.; Regenerative Medicine and Stem Cells Program, Australian Institute for Musculoskeletal Science (AIMSS), Melbourne, VIC 3021, Australia.
Jazyk: angličtina
Zdroj: Biomolecules [Biomolecules] 2024 Apr 06; Vol. 14 (4). Date of Electronic Publication: 2024 Apr 06.
DOI: 10.3390/biom14040447
Abstrakt: Krill oil is extracted from krill, a small crustacean in the Antarctic Ocean. It has received growing attention because of krill oil's unique properties and diverse health benefits. Recent experimental and clinical studies suggest that it has potential therapeutic benefits in preventing the development of a range of chronic conditions, including inflammatory bowel disease (IBD). Krill oil is enriched with long-chain n-3 polyunsaturated fatty acids, especially eicosapentaenoic and docosahexaenoic acids, and the potent antioxidant astaxanthin, contributing to its therapeutic properties. The possible underlying mechanisms of krill oil's health benefits include anti-inflammatory and antioxidant actions, maintaining intestinal barrier functions, and modulating gut microbiota. This review aims to provide an overview of the beneficial effects of krill oil and its bioactive components on intestinal inflammation and to discuss the findings on the molecular mechanisms associated with the role of krill oil in IBD prevention and treatment.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
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