Effect of Sempervivum tectorum Extract on Some Biomarkers of Reproductive Function and Levels of Some Trace Elements in Male Rats Exposed to Aluminum.

Autor: Muselin F; Faculty of Veterinary Medicine, University of Life Sciences 'King Michael I', 300645 Timisoara, Romania.; Working Group for Xenobiochemistry, Romanian Academy-Branch, 300645 Timisoara, Romania., Dumitrescu E; Faculty of Veterinary Medicine, University of Life Sciences 'King Michael I', 300645 Timisoara, Romania., Doma AO; Faculty of Veterinary Medicine, University of Life Sciences 'King Michael I', 300645 Timisoara, Romania., Degi DM; Faculty of Veterinary Medicine, University of Life Sciences 'King Michael I', 300645 Timisoara, Romania., Degi J; Faculty of Veterinary Medicine, University of Life Sciences 'King Michael I', 300645 Timisoara, Romania., Savici J; Faculty of Veterinary Medicine, University of Life Sciences 'King Michael I', 300645 Timisoara, Romania., Grigorescu CC; Faculty of Medicine Bucharest, Titu Maiorescu University, 300645 Timisoara, Romania., Brezovan D; Faculty of Veterinary Medicine, University of Life Sciences 'King Michael I', 300645 Timisoara, Romania., Gencia I; Faculty of Medicine Timisoara, University of Medicine and Pharmacy 'Victor Babeș', 300645 Timisoara, Romania., Cristina RT; Faculty of Veterinary Medicine, University of Life Sciences 'King Michael I', 300645 Timisoara, Romania.
Jazyk: angličtina
Zdroj: Animals : an open access journal from MDPI [Animals (Basel)] 2024 Apr 16; Vol. 14 (8). Date of Electronic Publication: 2024 Apr 16.
DOI: 10.3390/ani14081196
Abstrakt: Aluminum, a contentious trace element found in the environment, has been demonstrated to have harmful effects on both humans and animals. In contrast, Sempervivum tectorum , an evergreen plant, has been found to offer numerous beneficial effects for both humans and animals. Therefore, this study aims to assess the protective effect of S. tectorum on certain reproductive biomarkers in male rats exposed to aluminum. Thirty-five Wistar rats were randomly divided into five groups: NTC (no-treatment control) received distilled water; NC (negative control) received drinking water containing 1 mg/L aluminum sulfate (AS); E1 received 1 mg/L AS along with an 8% S. tectorum extract; PC (positive control) received only 8% S. tectorum extract; E2 received 1 mg/L AS for three months followed by 8% extract for one month. The study analyzed testosterone, LH, FSH, body weight, and the histological structure of the testis, epididymis, and prostate, as well as the levels of zinc, manganese, copper, and iron in these organs. Significant decreases in body weight, testis, and epididymis size were observed in the aluminum-exposed groups compared to the control, whereas these decreases were not significant in the S. tectorum -treated groups compared to the control. Aluminum exposure led to significant decreases in testosterone and LH levels, with FSH levels showing a nonsignificant decrease in males, which were mitigated significantly by the administration of the plant extract. Histological analysis revealed alterations in the testis, epididymis, and prostate of the AS-exposed groups, including necrosis of seminiferous tubule epithelium and Leydig cells in the testis, and basal epithelial necrosis in the epididymis and prostate. Aluminum levels increased in all organs studied, while levels of zinc, copper, iron, and manganese decreased, showing a negative and significant correlation with aluminum levels. The aqueous extract of S. tectorum demonstrated a protective effect on certain studied biomarkers in male rats affected by aluminum exposure.
Competing Interests: The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
Databáze: MEDLINE
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