Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset.

Autor: Sharkey RJ; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Bacon C; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Peterson Z; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Rootes-Murdy K; Department of Psychology,, Georgia State University, Atlanta, GA, USA., Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM ISCIII, Barcelona, Spain., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM ISCIII, Barcelona, Spain., Karuk A; FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM ISCIII, Barcelona, Spain., Homan P; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich, 8008, Switzerland., Ji E; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich, 8008, Switzerland., Omlor W; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich, 8008, Switzerland., Homan S; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich, 8008, Switzerland., Georgiadis F; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich, 8008, Switzerland., Kaiser S; Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Kirschner M; Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Ehrlich S; Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Grotegerd D; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Goltermann J; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Stein F; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Brosch K; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Krug A; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Nenadic I; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Sim K; West Region, Institute of Mental Health, Singapore, Singapore., Spalletta G; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Banaj N; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Sponheim SR; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA., Demro C; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA., Ramsay IS; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA., King M; The MIND Research Network, Albuquerque, NM, USA., Quidé Y; School of Psychiatry, University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia., Green MJ; School of Psychiatry, University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia., Nguyen D; Department of Pediatric Neurology, University of California Irvine, Irvine, CA, USA., Preda A; Department of Pediatric Neurology, University of California Irvine, Irvine, CA, USA.; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA., Calhoun V; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GE, USA., Turner J; Department of Psychiatry and Behavioral Medicine, Ohio State University, Columbus, OH, USA., van Erp T; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA.; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA., Nickl-Jockschat T; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. thomas.nickl-jockschat@med.ovgu.de.; Department of Psychiatry, University of Iowa, Iowa City, IA, USA. thomas.nickl-jockschat@med.ovgu.de.; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. thomas.nickl-jockschat@med.ovgu.de.; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany. thomas.nickl-jockschat@med.ovgu.de.; German Center for Mental Health (DZPG), partner site Halle-Jena-Magdeburg, Magdeburg, Germany. thomas.nickl-jockschat@med.ovgu.de.; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Halle-Jena-Magdeburg, Magdeburg, Germany. thomas.nickl-jockschat@med.ovgu.de.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2024 Oct; Vol. 29 (10), pp. 3086-3096. Date of Electronic Publication: 2024 Apr 26.
DOI: 10.1038/s41380-024-02563-z
Abstrakt: Formal thought disorder (FTD) is a clinical key factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, the relationship between FTD symptom dimensions and patterns of regional brain volume loss in schizophrenia remains to be established in large cohorts. Even less is known about the cellular basis of FTD. Our study addresses these major obstacles by enrolling a large multi-site cohort acquired by the ENIGMA Schizophrenia Working Group (752 schizophrenia patients and 1256 controls), to unravel the neuroanatomy of FTD in schizophrenia and using virtual histology tools on implicated brain regions to investigate the cellular basis. Based on the findings of previous clinical and neuroimaging studies, we decided to separately explore positive, negative and total formal thought disorder. We used virtual histology tools to relate brain structural changes associated with FTD to cellular distributions in cortical regions. We identified distinct neural networks positive and negative FTD. Both networks encompassed fronto-occipito-amygdalar brain regions, but positive and negative FTD demonstrated a dissociation: negative FTD showed a relative sparing of orbitofrontal cortical thickness, while positive FTD also affected lateral temporal cortices. Virtual histology identified distinct transcriptomic fingerprints associated for both symptom dimensions. Negative FTD was linked to neuronal and astrocyte fingerprints, while positive FTD also showed associations with microglial cell types. These results provide an important step towards linking FTD to brain structural changes and their cellular underpinnings, providing an avenue for a better mechanistic understanding of this syndrome.
(© 2024. The Author(s).)
Databáze: MEDLINE
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