Metabolic Messengers: Thyroid Hormones.

Autor: Sinha RA; Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. anthony.rohit@gmail.com., Yen PM; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore. paul.yen@duke-nus.edu.sg.; Div. Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. paul.yen@duke-nus.edu.sg.
Jazyk: angličtina
Zdroj: Nature metabolism [Nat Metab] 2024 Apr; Vol. 6 (4), pp. 639-650. Date of Electronic Publication: 2024 Apr 26.
DOI: 10.1038/s42255-024-00986-0
Abstrakt: Thyroid hormones (THs) are key hormones that regulate development and metabolism in mammals. In man, the major target tissues for TH action are the brain, liver, muscle, heart, and adipose tissue. Defects in TH synthesis, transport, metabolism, and nuclear action have been associated with genetic and endocrine diseases in man. Over the past few years, there has been renewed interest in TH action and the therapeutic potential of THs and thyromimetics to treat several metabolic disorders such as hypercholesterolemia, dyslipidaemia, non-alcoholic fatty liver disease (NAFLD), and TH transporter defects. Recent advances in the development of tissue and TH receptor isoform-targeted thyromimetics have kindled new hope for translating our fundamental understanding of TH action into an effective therapy. This review provides a concise overview of the historical development of our understanding of TH action, its physiological and pathophysiological effects on metabolism, and future therapeutic applications to treat metabolic dysfunction.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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