Usefulness of serum amyloid A for the diagnosis of pyelonephritis in cats: A prospective evaluation.

Autor: Kurtz M; École Nationale Vétérinaire d'Alfort, CHUVA, Service de Médecine Interne, Maisons-Alfort, France., Pey PBM; Antech Imaging Services, Irvine, California, USA.; Veterinary Hospital 'I Portoni Rossi,' Anicura, Zola Predosa (BO), Bologna, Italy., Mortier J; Ecole Nationale Vétérinaire d'Alfort, CHUVA, Service D'Imagerie Médicale, Maisons-Alfort, France., Manassero M; École Nationale Vétérinaire d'Alfort, CHUVA, Service de Chirurgie, Maisons-Alfort, France., Da Riz F; École Nationale Vétérinaire d'Alfort, CHUVA, Service de Médecine Interne, Maisons-Alfort, France., Canonne-Guibert M; École Nationale Vétérinaire d'Alfort, CHUVA, Service de Médecine Interne, Maisons-Alfort, France.; Ecole Nationale Vétérinaire d'Alfort, CHUVA, Service D'Imagerie Médicale, Maisons-Alfort, France., Maurey C; École Nationale Vétérinaire d'Alfort, CHUVA, Service de Médecine Interne, Maisons-Alfort, France., Benchekroun G; École Nationale Vétérinaire d'Alfort, CHUVA, Service de Médecine Interne, Maisons-Alfort, France.; Ecole Nationale Vétérinaire d'Alfort, Univ Paris Est Créteil, INSERM, IMRB, Maisons-Alfort, France.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2024 May-Jun; Vol. 38 (3), pp. 1542-1552. Date of Electronic Publication: 2024 Apr 26.
DOI: 10.1111/jvim.17082
Abstrakt: Background: The diagnosis of pyelonephritis in cats is challenging and development of a noninvasive and accurate biomarker is needed.
Hypotheses: Serum amyloid A (SAA) is increased in cats with pyelonephritis, but not in cats with other urinary tract diseases.
Animals: A cohort of 125 cats (149 observations).
Methods: This was a prospective study. Group 1 included cats with a diagnosis of pyelonephritis either confirmed by bacterial culture of pelvic urine (Group 1a) or presumed (1b). Group 2 included cats for which pyelonephritis was ruled out (with certainty: Group 2a or judged unlikely: Group 2b). SAA concentration was compared between groups, and accuracy of SAA for the diagnosis of pyelonephritis was calculated using a Receiver Operating Characteristic (ROC) curve analysis.
Results: Median SAA concentration was significantly higher in Group 1a (86.8 mg/L [73.3; 161.5]; n = 8) than in Group 2a (4 mg/L [1.8; 5.6], n = 19; P < .001) and in Group 2b (5.4 mg/L [3.1; 9.7], n = 113; P < .001). It was also significantly higher in Group 1b (98.8 mg/L [83.1; 147.3]; n = 9) than in Group 2b (P < .001) and Group 2a (P < .001). Optimal diagnostic cut-off for SAA concentration was 51.3 mg/L. yielding a sensitivity of 88% (95% confidence interval: [64%; 99%]) and a specificity of 94% (95% confidence interval: [88%; 97%]).
Conclusions and Clinical Importance: Measurement of SAA could be used to rule out pyelonephritis in the case of low suspicion of the disease. Increased SAA concentration is suggestive of pyelonephritis despite a lack of specificity.
(© 2024 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
Externí odkaz: