| Autor: |
Staimez LR; Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Emory University, Atlanta, GA 30322, USA.; Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA., Dutta A; Centre for Chronic Disease Control, New Delhi 110016, Delhi, India., Beyh YS; Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Emory University, Atlanta, GA 30322, USA., Gupta R; Centre for Chronic Disease Control, New Delhi 110016, Delhi, India., Noule HK; Centre for Chronic Disease Control, New Delhi 110016, Delhi, India.; Share India, MediCiti Institute for Medical Sciences, Medchal 501401, Telangana, India.; Administrative Staff College of India, Hyderabad 500034, Telanaga, India., Sapna V; Share India, MediCiti Institute for Medical Sciences, Medchal 501401, Telangana, India., Deepa K; Share India, MediCiti Institute for Medical Sciences, Medchal 501401, Telangana, India., Stein AD; Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA., Narayan KMV; Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Emory University, Atlanta, GA 30322, USA.; Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA., Prabhakaran D; Centre for Chronic Disease Control, New Delhi 110016, Delhi, India.; Public Health Foundation of India, Gurgaon 110030, Haryana, India., Kalpana B; Share India, MediCiti Institute for Medical Sciences, Medchal 501401, Telangana, India., Prabhakaran P; Centre for Chronic Disease Control, New Delhi 110016, Delhi, India. |
| Abstrakt: |
The Asian Indian Beta Cell function (ABCs) in Infants Study examined the associations of maternal weight on infant pancreatic beta cell function across 7 months postpartum. Pregnant women aged 18-35 years were recruited in Hyderabad, India. Women were classified by first trimester weight as underweight (UW), BMI < 18.5 kg/m 2 ; normal weight (NW), BMI 18.5-22.9 kg/m 2 ; or overweight (OW), BMI 23.0 through <28.5 kg/m 2 . At age > 7 months, infants had an oral glucose tolerance test (OGTT, 1.75 g glucose/kg bodyweight) following a 3 h fast. Infant blood samples were assayed for C-peptide and glucose. Infant beta cell function (HOMA2-B; disposition index, DI) and insulin resistance (HOMA2-IR) were compared across maternal weight groups. Mothers (UW n = 63; NW n = 43; OW n = 29) had similar age at delivery and second trimester 50 g glucose challenge test results. Cord HOMA2-B values were 51% greater for I UW (83.5, SD 55.2) and 44% greater for I OW (79.9, SD 60.8) vs. I NW (55.4, SD 51.5), forming a U-shaped relationship between maternal weight and HOMA2-B. No qualitative differences in HOMA2-IR were found at birth. However, at 7 months postpartum, HOMA2-IR changed most within I UW (-64% median reduction) and changed the least in I OW (-7% median reduction). At seven months postpartum, DI was higher in I UW vs. the other groups (geometric mean I UW 1.9 SD 2.5; I NW 1.3 SD 2.6 or vs. I OW mean 1.2 SD 3.7), reflecting a +49% difference in DI. Evidence from this study illustrates adaptations in the pancreatic functional response of infants associated with the maternal nutritional environment. |
