Synthesis and Medicinal Applications of N-Heterocyclic Carbene Complexes Based on Caffeine and Other Xanthines.

Autor: Francescato G; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da Republica, 2780-157, Oeiras, Portugal., Leitão MIPS; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da Republica, 2780-157, Oeiras, Portugal., Orsini G; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da Republica, 2780-157, Oeiras, Portugal., Petronilho A; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da Republica, 2780-157, Oeiras, Portugal.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2024 Aug 01; Vol. 19 (15), pp. e202400118. Date of Electronic Publication: 2024 Jun 14.
DOI: 10.1002/cmdc.202400118
Abstrakt: Xanthines are purine derivatives predominantly found in plants. These include compounds such as caffeine, theophylline, and theobromine and exhibit a variety of pharmacological properties, demonstrating efficacy in treating neurodegenerative disorders, respiratory dysfunctions, and also cancer. The versatile attributes of these materials render them privileged scaffolds for the development of compounds for various biological applications. Xanthines are N-heterocyclic carbene precursors that combine a pyrimidine and an imidazole ring. Owing to their biological relevance, xanthines have been employed as N-heterocyclic carbenes in the development of metallodrugs for anticancer and antimicrobial purposes. In this conceptual review, we examine key examples of N-heterocyclic carbene complexes derived from caffeine and other xanthines, elucidating their synthetic methods and describing their pertinent medicinal applications.
(© 2024 The Authors. ChemMedChem published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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