The Role of Cytokines in the Pathogenesis and Treatment of Alcoholic Liver Disease.

Autor: Scarlata GGM; Department of Health Sciences, University 'Magna Græcia', Viale Europa, 88100 Catanzaro, Italy., Colaci C; Department of Health Sciences, University 'Magna Græcia', Viale Europa, 88100 Catanzaro, Italy., Scarcella M; Anesthesia, Intensive Care and Nutritional Science, Azienda Ospedaliera 'Santa Maria', Via Tristano di Joannuccio, 05100 Terni, Italy., Dallio M; Hepatogastroenterology Division, Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Piazza Miraglia 2, 80138 Naples, Italy., Federico A; Hepatogastroenterology Division, Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Piazza Miraglia 2, 80138 Naples, Italy., Boccuto L; Healthcare Genetics and Genomics Doctoral Program, School of Nursing, College of Behavioral, Social and Health Sciences, Clemson University, Clemson, SC 29634, USA., Abenavoli L; Department of Health Sciences, University 'Magna Græcia', Viale Europa, 88100 Catanzaro, Italy.
Jazyk: angličtina
Zdroj: Diseases (Basel, Switzerland) [Diseases] 2024 Mar 29; Vol. 12 (4). Date of Electronic Publication: 2024 Mar 29.
DOI: 10.3390/diseases12040069
Abstrakt: Alcoholic liver disease (ALD) is a major cause of chronic liver disease. This term covers a broad spectrum of liver lesions, from simple steatosis to alcoholic hepatitis and cirrhosis. The pathogenesis of ALD is multifactorial and not fully elucidated due to complex mechanisms related to direct ethanol toxicity with subsequent hepatic and systemic inflammation. The accumulation of pro-inflammatory cytokines and the reduction of anti-inflammatory cytokines promote the development and progression of ALD. To date, there are no targeted therapies to counter the progression of chronic alcohol-related liver disease and prevent acute liver failure. Corticosteroids reduce mortality by acting on the hepatic-systemic inflammation. On the other hand, several studies analyzed the effect of inhibiting pro-inflammatory cytokines and stimulating anti-inflammatory cytokines as potential therapeutic targets in ALD. This narrative review aims to clarify the role of the main cytokines involved in the pathogenesis and treatment of ALD.
Databáze: MEDLINE
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