| Autor: |
de Morais LA; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil., Souza Neto FN; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil., Hosida TY; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil., Dos Santos DM; Sao Carlos Institute of Chemistry, University of Sao Paulo, Av. Trabalhador Sao-Carlense, 400, São Carlos 13566-590, São Paulo, Brazil., de Almeida BC; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil., Frollini E; Sao Carlos Institute of Chemistry, University of Sao Paulo, Av. Trabalhador Sao-Carlense, 400, São Carlos 13566-590, São Paulo, Brazil., Filho SPC; Sao Carlos Institute of Chemistry, University of Sao Paulo, Av. Trabalhador Sao-Carlense, 400, São Carlos 13566-590, São Paulo, Brazil., Barbosa DB; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil., de Camargo ER; Center for Exact Sciences and Technology, Federal University of São Carlos (UFSCAR), Av. Trab. São Carlense, 400, São Carlos 13566-590, São Paulo, Brazil., Delbem ACB; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil. |
| Abstrakt: |
This study aimed to develop a polymeric matrix of polyamide-6 (P6) impregnated with trimetaphosphate (TMP) nanoparticles and silver nanoparticles (AgNPs), and to evaluate its antimicrobial activity, surface free energy, TMP and Ag + release, and cytotoxicity for use as a support in dental tissue. The data were subjected to statistical analysis ( p < 0.05). P6 can be incorporated into TMP without altering its properties. In the first three hours, Ag + was released for all groups decorated with AgNPs, and for TMP, the release only occurred for the P6-TMP-5% and P6-TMP-10% groups. In the inhibition zones, the AgNPs showed activity against both microorganisms. The P6-TMP-2.5%-Ag and P6-TMP-5%-Ag groups with AgNPs showed a greater reduction in CFU for S. mutans . For C. albicans , all groups showed a reduction in CFU. The P6-TMP groups showed higher cell viability, regardless of time ( p < 0.05). The developed P6 polymeric matrix impregnated with TMP and AgNPs demonstrated promising antimicrobial properties against the tested microorganisms, making it a potential material for applications in scaffolds in dental tissues. |
