Exploring Memory Function Beyond Immune Cells: ANGPTL4-Mediated Memory Functions in Tissue Resident Stem Cells.

Autor: Park SR; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, Republic of Korea.; Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 406-840, Republic of Korea., Min EK; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, Republic of Korea.; Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 406-840, Republic of Korea., Kim SR; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, Republic of Korea.; Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 406-840, Republic of Korea., Kim SK; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, Republic of Korea.; Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 406-840, Republic of Korea., Na KH; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, Republic of Korea.; Department of Microbiology, College of Medicine, Gachon University, Incheon, 21999, Republic of Korea., Park CH; Department of Otolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, 24201, Republic of Korea., Jung Y; Department of Microbiology, College of Medicine, Gachon University, Incheon, 21999, Republic of Korea., Oh BC; Department of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, 21999, Republic of Korea., Hong IS; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, Republic of Korea.; Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 406-840, Republic of Korea.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jul; Vol. 11 (28), pp. e2307545. Date of Electronic Publication: 2024 Apr 26.
DOI: 10.1002/advs.202307545
Abstrakt: Adapted immune cells are known to develop memory functions that increase resistance to subsequent infections after initial pathogen exposure, however, it is unclear whether non-immune cells, like tissue-resident stem cells, have similar memory functions. Here, it is found that tissue-resident stem cells crucial for tissue regeneration show diminished adverse effects on diverse stem cell functions against successive exposure to foreign antigen (β-glucan) to maintain tissue homeostasis and stability both in vitro and in vivo. These data suggest that endometrial stem cells may possess a robust memory function, in contrast, fully differentiated cells like fibroblasts and vesicular cells do not show these memory mechanisms upon consecutive antigen exposure. Moreover, the pivotal role of Angiopoietin-like 4 (ANGPTL4) in regulating the memory functions of endometrial stem cells is identified through specific shRNA knockdown in vitro and knockout mice in vivo experiments. ANGPTL4 is associated with the alteration of diverse stem cell functions and epigenetic modifications, notably through histone H3 methylation changes and two pathways (i.e., PI3K/Akt and FAK/ERK1/2 signaling) upon consecutive antigen exposure. These findings imply the existence of inherent self-defense mechanisms through which local stem cells can adapt and protect themselves from recurrent antigenic challenges, ultimately mitigating adverse consequences.
(© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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