Prevalence of high-risk HPV and cervical dysplasia in IUD users and controls: a cross sectional study.

Autor:	Jans L; Department of Women's Health, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Brynhildsen J; Department of Women's Health, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Cherif E; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Tenerz L; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Bergengren L; Department of Women's Health, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Jazyk:	angličtina
Zdroj:	The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception [Eur J Contracept Reprod Health Care] 2024 Jun; Vol. 29 (3), pp. 109-114. Date of Electronic Publication: 2024 Apr 26.
DOI:	10.1080/13625187.2024.2340521
Abstrakt:	Objective: To examine the prevalence of infections with high-risk human papillomavirus (HPV) and cervical dysplasia, and the clearance rate of HPV infections, in users of different kinds of intrauterine devices (IUDs) and other contraceptive methods. Methods: A cross-sectional register-based study including 16,181 women aged 30-49 years participating in the screening programme for cervical cancer in a Swedish County in 2017-2018. Data on contraception from screening records was paired with the HPV test results, cytological and histological follow-up tests and subsequent HPV test. Results: There was no difference in the risk of being HPV positive, or histological HSIL+, between users of copper-containing IUDs and women with no reported use of contraception. Use of levonorgestrel intrauterine system and hormonal contraception were associated with higher odds for HPV infection in age-adjusted models (aOR 1.21; 95% CI 1.04-1.41, and aOR 1.41; 95% CI 1.22-1.63, respectively) and for HSIL+ (aOR 1.45; 95% CI 1.02-2.06, and aOR 1.56; 95% CI 1.13-2.16, respectively). No significant differences were found in HPV clearance rates. Conclusions: Reported use of levonorgestrel intrauterine system and hormonal contraception, but not use of copper IUD, was associated with a higher prevalence of HPV infections and histological HSIL + compared to no reported use of contraception.
Databáze:	MEDLINE
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