Posterior Tibial Nerve Ultrasound Assessment of Peripheral Neuropathy in Adults with Type 2 Diabetes Mellitus.

Autor:	Oduola-Owoo LT; Department of Radiology, Federal Medical Centre, Lagos, Nigeria., Adeyomoye AA; Department of Radiation Biology, Radiotherapy and Radiodiagnosis, College of Medicine, University of Lagos, Lagos, Nigeria., Omidiji OA; Department of Radiation Biology, Radiotherapy and Radiodiagnosis, College of Medicine, University of Lagos, Lagos, Nigeria., Idowu BM; Department of Radiology, Union Diagnostics and Clinical Services PLC, Lagos, Nigeria., Oduola-Owoo BB; Department of Obstetrics and Gynaecology, Federal Medical Centre, Lagos, Nigeria., Odeniyi IA; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria.
Jazyk:	angličtina
Zdroj:	Journal of medical ultrasound [J Med Ultrasound] 2023 Aug 03; Vol. 32 (1), pp. 62-69. Date of Electronic Publication: 2023 Aug 03 (Print Publication: 2024).
DOI:	10.4103/jmu.jmu_13_23
Abstrakt:	Background: Diabetic peripheral neuropathy (DPN) is a common and debilitating complication of type 2 diabetes mellitus (T2DM). Early detection and prompt institution of appropriate therapy could prevent undesirable outcomes such as paresthesia, pain, and amputation. Although the gold standard for diagnosing DPN is nerve conduction studies, high-resolution peripheral nerve ultrasonography may serve as a noninvasive and low-cost alternative for diagnosing and staging DPN. This study investigated the clinical utility of sonographic posterior tibial nerve cross-sectional area (PTN CSA) for diagnosing DPN in individuals with T2DM. Methods: Eighty consecutive adults with T2DM and 80 age-/sex-matched controls were recruited. Clinical information was obtained, including symptoms, disease duration, Toronto clinical neuropathy score (TCNS), and biochemical parameters. The left PTN CSA at 1 cm, 3 cm, and 5 cm above the medial malleolus (MM) was measured with a high-frequency ultrasound transducer and compared to the detection of DPN using the TCNS. Results: Based on the TCNS, 58 (72.5%) of the T2DM group had DPN. Of these, 14 (24.1%), 16 (27.6%), and 28 (48.3%) participants had mild, moderate, and severe DPN, respectively. All the mean PTN CSA (aggregate, 1 cm, 3 cm, and 5 cm above MM) of the participants with T2DM and DPN (T2DM-DPN) were significantly higher than those of T2DM without DPN (WDPN) and controls. All the PTN CSA increased significantly with increasing severity of DPN. The PTN CSA at 3 and 5 cm levels correlated weakly but significantly with fasting plasma glucose and glycated hemoglobin levels. Conclusion: The PTN CSA is significantly larger in T2DM-DPN than in T2DM-WDPN and healthy controls. PTN ultrasonography can be an additional tool for screening DPN in patients with T2DM. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 Journal of Medical Ultrasound.)
Databáze:	MEDLINE
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