The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder.

Autor:	Chen X; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China., Lu B; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China., Li HX; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China., Li XY; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China.; Sino-Danish Center for Education and Research, Graduate University of Chinese Academy of Sciences, Beijing 101408, China., Wang YW; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China., Castellanos FX; Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, USA.; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, NY 10962, USA., Cao LP; Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China., Chen NX; Capital Normal University, Beijing 100089, China., Chen W; Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, Zhejiang, China., Cheng YQ; Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China., Cui SX; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China.; Sino-Danish Center for Education and Research, Graduate University of Chinese Academy of Sciences, Beijing 101408, China., Deng ZY; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China., Fang YR; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China., Gong QY; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan 610052, China., Guo WB; Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China., Hu ZJ; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China., Kuang L; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China., Li BJ; Xijing Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China., Li L; Center for Cognitive Science of Language, Beijing Language and Culture University, Beijing 100083, China., Li T; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310063, China.; Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China., Lian T; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China., Liao YF; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China., Liu YS; Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu 215003, China., Liu ZN; Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China., Lu JP; Shenzhen Kangning Hospital, Shenzhen, Guangzhou 518020, China., Luo QH; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China., Meng HQ; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China., Peng DH; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China., Qiu J; Faculty of Psychology, Southwest University, Chongqing 400715, China., Shen YD; Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou, Zhejiang 311121, China., Si TM; National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China., Tang YQ; Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110122, China., Wang CY; Beijing Anding Hospital, Capital Medical University, Beijing 100120, China., Wang F; Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110122, China.; Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210024, China., Wang HN; Xijing Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China., Wang K; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China., Wang X; Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China., Wang Y; The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 250024, China., Wang ZH; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China., Wu XP; Xi'an Central Hospital, Xi'an, Shaanxi 710004, China., Xie CM; Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, China., Xie GR; Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China., Xie P; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China.; Chongqing Key Laboratory of Neurobiology, Chongqing 400000, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China., Xu XF; Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China., Yang H; Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China., Yang J; Chongqing Key Laboratory of Neurobiology, Chongqing 400000, China., Yao SQ; Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China., Yu YQ; The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China., Yuan YG; Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China., Zhang KR; First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China., Zhang W; West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China., Zhang ZJ; Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, China., Zhu JJ; Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zuo XN; Developmental Population Neuroscience Research Center, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100091, China.; National Basic Science Data Center, Beijing 100038, China., Zhao JP; Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China., Zang YF; Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310018, China.; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang 310000, China., Yan CG; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China.; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China.; Sino-Danish Center for Education and Research, Graduate University of Chinese Academy of Sciences, Beijing 101408, China.
Jazyk:	angličtina
Zdroj:	Psychoradiology [Psychoradiology] 2022 Jun 09; Vol. 2 (1), pp. 32-42. Date of Electronic Publication: 2022 Jun 09 (Print Publication: 2022).
DOI:	10.1093/psyrad/kkac005
Abstrakt:	Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder (MDD), reproducible findings are lacking, probably reflecting mostly small sample sizes and heterogeneity in analytic approaches. To address these issues, the Depression Imaging REsearch ConsorTium (DIRECT) was launched. The REST-meta-MDD project, pooling 2428 functional brain images processed with a standardized pipeline across all participating sites, has been the first effort from DIRECT. In this review, we present an overview of the motivations, rationale, and principal findings of the studies so far from the REST-meta-MDD project. Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network, in whole-brain topological properties, in dynamic features, and in functional lateralization. These well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven research. Following these fruitful explorations, DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations. A state-of-the-art, surface-based preprocessing pipeline has also been introduced to improve sensitivity. Functional images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diagnosis boundaries. In addition, large-scale longitudinal studies targeting brain network alterations following antidepressant treatment, aggregation of diffusion tensor images, and the development of functional magnetic resonance imaging-guided neuromodulation approaches are underway. Through these endeavours, we hope to accelerate the translation of functional neuroimaging findings to clinical use, such as evaluating longitudinal effects of antidepressant medications and developing individualized neuromodulation targets, while building an open repository for the scientific community. Competing Interests: One of the authors, Dr Qi-Yong Gong, is also the editor-in-chief of Psychoradiology. He was blinded from reviewing or making decisions on the manuscript. (© The Author(s) 2022. Published by Oxford University Press on behalf of West China School of Medicine/West China Hospital (WCSM/WCH) of Sichuan University.)
Databáze:	MEDLINE
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