Neuroprotective effect of acetoxypachydiol against oxidative stress through activation of the Keap1-Nrf2/HO-1 pathway.
Autor: | Qi Y; School of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China., Liu G; Department of pharmacy, Yongkang First People's Hospital Affiliated to Hangzhou Medical College, Yongkang, 321300, People's Republic of China., Jin S; School of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China., Jian R; School of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China., Zou Z; School of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China., Wang C; School of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China., Zhang Y; School of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China., Zhao M; School of Pharmaceutical Sciences, Wenzhou Medical University, Chashan University Town, Ouhai District, Wenzhou, Zhejiang, 325035, People's Republic of China., Zhu H; School of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China. zhuhaoru@wmu.edu.cn., Yan P; School of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China. yanpc@wmu.edu.cn. |
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Jazyk: | angličtina |
Zdroj: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2024 Apr 25; Vol. 24 (1), pp. 175. Date of Electronic Publication: 2024 Apr 25. |
DOI: | 10.1186/s12906-024-04474-6 |
Abstrakt: | Background: Excessive oxidative stress in the brain is an important pathological factor in neurological diseases. Acetoxypachydiol (APHD) is a lipophilic germacrane-type diterpene extracted as a major component from different species of brown algae within the genus Dictyota. There have been no previous reports on the pharmacological activity of APHD. The present research aims to explore the potential neuroprotective properties of APHD and its underlying mechanisms. Methods: The possible mechanism of APHD was predicted using a combination of molecular docking and network pharmacological analysis. PC12 cells were induced by H Results: APHD exhibited antioxidant activity in both PC12 cells subjected to H Conclusions: APHD activated antioxidant enzymes and downregulated the levels of LDH, MDA, and ROS in two cell models. The neuroprotective effect is presumably reliant on upregulation of the Keap1-Nrf2/HO-1 pathway. Taken together, APHD from brown algae of the genus Dictyota shows potential as a candidate for novel neuroprotective agents. (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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