Post-translational modifications in kidney diseases and associated cardiovascular risk.

Autor: Noels H; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany. hnoels@ukaachen.de.; Aachen-Maastricht Institute for Cardiorenal Disease (AMICARE), University Hospital RWTH Aachen, Aachen, Germany. hnoels@ukaachen.de.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands. hnoels@ukaachen.de., Jankowski V; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; Aachen-Maastricht Institute for Cardiorenal Disease (AMICARE), University Hospital RWTH Aachen, Aachen, Germany., Schunk SJ; Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University, Homburg/Saar, Germany., Vanholder R; Nephrology Section, Department of Internal Medicine and Paediatrics, University Hospital, Ghent, Belgium.; European Kidney Health Alliance (EKHA), Brussels, Belgium., Kalim S; Department of Medicine, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Jankowski J; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany. jjankowski@ukaachen.de.; Aachen-Maastricht Institute for Cardiorenal Disease (AMICARE), University Hospital RWTH Aachen, Aachen, Germany. jjankowski@ukaachen.de.; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands. jjankowski@ukaachen.de.
Jazyk: angličtina
Zdroj: Nature reviews. Nephrology [Nat Rev Nephrol] 2024 Aug; Vol. 20 (8), pp. 495-512. Date of Electronic Publication: 2024 Apr 25.
DOI: 10.1038/s41581-024-00837-x
Abstrakt: Patients with chronic kidney disease (CKD) are at an increased cardiovascular risk compared with the general population, which is driven, at least in part, by mechanisms that are uniquely associated with kidney disease. In CKD, increased levels of oxidative stress and uraemic retention solutes, including urea and advanced glycation end products, enhance non-enzymatic post-translational modification events, such as protein oxidation, glycation, carbamylation and guanidinylation. Alterations in enzymatic post-translational modifications such as glycosylation, ubiquitination, acetylation and methylation are also detected in CKD. Post-translational modifications can alter the structure and function of proteins and lipoprotein particles, thereby affecting cellular processes. In CKD, evidence suggests that post-translationally modified proteins can contribute to inflammation, oxidative stress and fibrosis, and induce vascular damage or prothrombotic effects, which might contribute to CKD progression and/or increase cardiovascular risk in patients with CKD. Consequently, post-translational protein modifications prevalent in CKD might be useful as diagnostic biomarkers and indicators of disease activity that could be used to guide and evaluate therapeutic interventions, in addition to providing potential novel therapeutic targets.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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