Influence of substance use on male reproductive health and offspring outcomes.

Autor: Lo JO; Department of Urology, Oregon Heath & Science University, Portland, OR, USA. loj@ohsu.edu.; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA. loj@ohsu.edu.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA. loj@ohsu.edu., Hedges JC; Department of Urology, Oregon Heath & Science University, Portland, OR, USA.; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA., Chou WH; Department of Urology, Oregon Heath & Science University, Portland, OR, USA., Tager KR; Department of Environmental Health Science, University of Georgia College of Public Health, Athens, GA, USA., Bachli ID; Department of Environmental Health Science, University of Georgia College of Public Health, Athens, GA, USA., Hagen OL; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA., Murphy SK; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA., Hanna CB; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA., Easley CA 4th; Department of Environmental Health Science, University of Georgia College of Public Health, Athens, GA, USA.
Jazyk: angličtina
Zdroj: Nature reviews. Urology [Nat Rev Urol] 2024 Sep; Vol. 21 (9), pp. 534-564. Date of Electronic Publication: 2024 Apr 25.
DOI: 10.1038/s41585-024-00868-w
Abstrakt: The prevalence of substance use globally is rising and is highest among men of reproductive age. In Africa, and South and Central America, cannabis use disorder is most prevalent and in Eastern and South-Eastern Europe, Central America, Canada and the USA, opioid use disorder predominates. Substance use might be contributing to the ongoing global decline in male fertility, and emerging evidence has linked paternal substance use with short-term and long-term adverse effects on offspring development and outcomes. This trend is concerning given that substance use is increasing, including during the COVID-19 pandemic. Preclinical studies have shown that male preconception substance use can influence offspring brain development and neurobehaviour through epigenetic mechanisms. Additionally, human studies investigating paternal health behaviours during the prenatal period suggest that paternal tobacco, opioid, cannabis and alcohol use is associated with reduced offspring mental health, in particular hyperactivity and attention-deficit hyperactivity disorder. The potential effects of paternal substance use are areas in which to focus public health efforts and health-care provider counselling of couples or individuals interested in conceiving.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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