Cross-species spill-over potential of the H9N2 bat influenza A virus.

Autor: El-Shesheny R; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, Egypt., Franks J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Kandeil A; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, Egypt.; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Badra R; Human Link, Dubai, United Arab Emirates., Turner J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Seiler P; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Marathe BM; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Jeevan T; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Kercher L; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Hu M; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Sim YE; Department of Biology, Wanek School of Natural Science, High Point University, High Point, NC, USA., Hui KPY; School of Public Health, The University of Hong Kong, Hong Kong, China., Chan MCW; School of Public Health, The University of Hong Kong, Hong Kong, China., Thompson AJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., McKenzie P; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Govorkova EA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Russell CJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Vogel P; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Paulson JC; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Peiris JSM; School of Public Health, The University of Hong Kong, Hong Kong, China., Webster RG; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Ali MA; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, Egypt., Kayali G; Human Link, Dubai, United Arab Emirates. ghazi@human-link.org., Webby RJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA. Richard.Webby@stjude.org.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Apr 25; Vol. 15 (1), pp. 3449. Date of Electronic Publication: 2024 Apr 25.
DOI: 10.1038/s41467-024-47635-4
Abstrakt: In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus-like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.
(© 2024. The Author(s).)
Databáze: MEDLINE
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