TBS correlates with bone density and microstructure at trabecular and cortical bone evaluated by HR-pQCT.

Autor: Gama EMF; Division of Endocrinology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil. dudagama01@gmail.com., Mendonça LMC; Division of Rheumatology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil., Paranhos-Neto FP; Division of Endocrinology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil., Vieira Neto L; Division of Endocrinology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil., Madeira M; Division of Endocrinology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil., Farias MLF; Division of Endocrinology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil.
Jazyk: angličtina
Zdroj: Journal of bone and mineral metabolism [J Bone Miner Metab] 2024 May; Vol. 42 (3), pp. 352-360. Date of Electronic Publication: 2024 Apr 25.
DOI: 10.1007/s00774-024-01508-4
Abstrakt: Introduction: Trabecular bone score (TBS) estimates bone microstructure, which is directly measured by high-resolution peripheral quantitative computed tomography (HRpQCT). We evaluated the correlation between these methods and TBS influence on fracture risk assessed by FRAX.
Materials and Methods: We evaluated 129 individuals (82 women, 43 postmenopausal) 20 to 82.3 years without prevalent clinical or non-clinical morphometric vertebral fractures, using DXA (spine and hip), HR-pQCT at distal radius (R) and tibia (T) and TBS which classifies bone microarchitecture as normal (TBS ≥ 1.350), partially degraded (1.200 < TBS < 1.350), or degraded (TBS ≤ 1.200).
Results: Spine and hip BMD and HR-pQCT parameters at cortical bone: area (T), density (R,T) thickness (T) and trabecular bone: density (R,T), number (T) and thickness (R) were significantly better in the 78 individuals with normal TBS (group 1) versus the 51 classified as partially degraded (n = 42) or degraded microarchitecture (n = 9) altogether (group 2). TBS values correlated with age (r = - 0.55), positively with spine and hip BMD and all cortical and trabecular bone density and microstructure parameters evaluated, p < 0.05 all tests. Binary logistic regression defined age (p = 0.008) and cortical thickness (p = 0.018) as main influences on TBS, while ANCOVA demonstrated that HR-pQCT data corrected for age were not different between TBS groups 1 and 2. TBS adjustment increased FRAX risk for major osteoporotic fractures and hip fractures.
Conclusion: We describe significant association between TBS and both trabecular and cortical bone parameters measured by HR-pQCT, consistent with TBS influence on fracture risk estimation by FRAX, including hip fractures, where cortical bone predominates.
(© 2024. The Japanese Society Bone and Mineral Research.)
Databáze: MEDLINE
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