Prospective cohort study of long-term neurological outcomes in retired elite athletes: the Advanced BiomaRker, Advanced Imaging and Neurocognitive (BRAIN) Health Study protocol.

Autor:	Zimmerman KA; Centre for Care, Research and Technology, UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Centre for Injury Studies, Imperial College London, London, UK., Hain JA; Centre for Care, Research and Technology, UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Graham NSN; Centre for Care, Research and Technology, UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Centre for Injury Studies, Imperial College London, London, UK., Rooney EJ; Centre for Care, Research and Technology, UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Institute of Sport, Exercise and Health (ISEH), University College London, London, UK., Lee Y; Centre for Care, Research and Technology, UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Institute of Sport, Exercise and Health (ISEH), University College London, London, UK., Del-Giovane M; Centre for Care, Research and Technology, UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Parker TD; Centre for Care, Research and Technology, UK Dementia Research Institute, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Neurodegenerative Disease, The Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Friedland D; Department of Brain Sciences, Imperial College London, London, UK.; Institute of Sport, Exercise and Health (ISEH), University College London, London, UK., Cross MJ; Carnegie Applied Rugby Research Centre, Carnegie School of Sport, Leeds Beckett University, Leeds, UK.; Premiership Rugby, London, UK., Kemp S; Rugby Football Union, Twickenham, UK.; London School of Hygiene & Tropical Medicine, London, UK., Wilson MG; Institute of Sport, Exercise and Health (ISEH), University College London, London, UK.; HCA Healthcare Research Institute, London, UK., Sylvester RJ; Institute of Sport, Exercise and Health (ISEH), University College London, London, UK.; Acute Stroke and Brain Injury Unit, National Hospital for Neurology and Neurosurgery, London, UK., Sharp DJ; Centre for Care, Research and Technology, UK Dementia Research Institute, Imperial College London, London, UK david.sharp@imperial.ac.uk.; Department of Brain Sciences, Imperial College London, London, UK.; Centre for Injury Studies, Imperial College London, London, UK.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2024 Apr 24; Vol. 14 (4), pp. e082902. Date of Electronic Publication: 2024 Apr 24.
DOI:	10.1136/bmjopen-2023-082902
Abstrakt:	Introduction: Although limited, recent research suggests that contact sport participation might have an adverse long-term effect on brain health. Further work is required to determine whether this includes an increased risk of neurodegenerative disease and/or subsequent changes in cognition and behaviour. The Advanced BiomaRker, Advanced Imaging and Neurocognitive Health Study will prospectively examine the neurological, psychiatric, psychological and general health of retired elite-level rugby union and association football/soccer players. Methods and Analysis: 400 retired athletes will be recruited (200 rugby union and 200 association football players, male and female). Athletes will undergo a detailed clinical assessment, advanced neuroimaging, blood testing for a range of brain health outcomes and neuropsychological assessment longitudinally. Follow-up assessments will be completed at 2 and 4 years after baseline visit. 60 healthy volunteers will be recruited and undergo an aligned assessment protocol including advanced neuroimaging, blood testing and neuropsychological assessment. We will describe the previous exposure to head injuries across the cohort and investigate relationships between biomarkers of brain injury and clinical outcomes including cognitive performance, clinical diagnoses and psychiatric symptom burden. Ethics and Dissemination: Relevant ethical approvals have been granted by the Camberwell St Giles Research Ethics Committee (Ref: 17/LO/2066). The study findings will be disseminated through manuscripts in clinical/academic journals, presentations at professional conferences and through participant and stakeholder communications. Competing Interests: Competing interests: DJS is funded by the UK Dementia Research Institute and has received an honorarium from the Rugby Football Union for participation in an expert concussion panel. DJS, RJS and DF receive payment by RFU/FA/PRL/PFA for private clinical services at ISEH. SK is employed by the Rugby Football Union as Medical Services Director. MJC is employed by Premiership Rugby as Head of Science and Medical Operations. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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