The influence of long-range transported Saharan dust on the inflammatory potency of ambient PM 2.5 and PM 10 .

Autor: Bredeck G; IUF - Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Auf'm Hennekamp 50, Germany., Dos S Souza EJ; Atmospheric Chemistry Department (ACD), Leibniz-Institute for Tropospheric Research (TROPOS), 04318, Leipzig, Permoserstr. 15, Germany., Wigmann C; IUF - Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Auf'm Hennekamp 50, Germany., Fomba KW; Atmospheric Chemistry Department (ACD), Leibniz-Institute for Tropospheric Research (TROPOS), 04318, Leipzig, Permoserstr. 15, Germany., Herrmann H; Atmospheric Chemistry Department (ACD), Leibniz-Institute for Tropospheric Research (TROPOS), 04318, Leipzig, Permoserstr. 15, Germany., Schins RPF; IUF - Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Auf'm Hennekamp 50, Germany. Electronic address: roel.schins@iuf-duesseldorf.de.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Jul 01; Vol. 252 (Pt 3), pp. 119008. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1016/j.envres.2024.119008
Abstrakt: Although desert dust promotes morbidity and mortality, it is exempt from regulations. Its health effects have been related to its inflammatory properties, which can vary between source regions. It remains unclear which constituents cause this variability. Moreover, whether long-range transported desert dust potentiates the hazardousness of local particulate matter (PM) is still unresolved. We aimed to assess the influence of long-range transported desert dust on the inflammatory potency of PM 2.5 and PM 10 collected in Cape Verde and to examine associated constituents. During a reference period and two Saharan dust events, 63 PM 2.5 and PM 10 samples were collected at four sampling stations. The content of water-soluble ions, elements, and organic and elemental carbon was measured in all samples and endotoxins in PM 10 samples. The PM-induced release of inflammatory cytokines from differentiated THP-1 macrophages was evaluated. The association of interleukin (IL)-1β release with PM composition was assessed using principal component (PC) regressions. PM 2.5 from both dust events and PM 10 from one event caused higher IL-1β release than PM from the reference period. PC regressions indicated an inverse relation of IL-1β release with sea spray ions in both size fractions and organic and elemental carbon in PM 2.5 . The PC with the higher regression coefficient suggested that iron and manganese may contribute to PM 2.5 -induced IL-1β release. Only during the reference period, endotoxin content strongly differed between sampling stations and correlated with inflammatory potency. Our results demonstrate that long-range transported desert dust amplifies the hazardousness of local air pollution and suggest that, in PM 2.5 , iron and manganese may be important. Our data indicate that endotoxins are contained in local and long-range transported PM 10 but only explain the variability in inflammatory potency of local PM 10 . The increasing inflammatory potency of respirable and inhalable PM from desert dust events warrants regulatory measures and risk mitigation strategies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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