Hemophagocytic lymphohistiocytosis associated with brucellosis.

Autor: Guo M; Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China., Zhang L; Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China., Chen K; Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China., Huang D; Medical center of Hematology, Xinqiao Hospital, Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400037, China., Feng C; Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China., Liu H; Medical center of Hematology, Xinqiao Hospital, Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400037, China., Quan N; Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China., Meng F; Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China., Deng X; Medical center of Hematology, Xinqiao Hospital, Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400037, China., Liu F; Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. Electronic address: susufei@sina.com.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2024 Jul; Vol. 109 (3), pp. 116289. Date of Electronic Publication: 2024 Mar 28.
DOI: 10.1016/j.diagmicrobio.2024.116289
Abstrakt: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder categorized as familial HLH or secondary HLH. Our case report describes a 63-year-old woman with epilepsy whose clinical signs were unremitting fever and altered consciousness. Primary abnormalities consisted of fever, splenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia and hemophagocytosis in the bone marrow. Results of blood next generation sequencing and blood culture confirmed Brucella infection. This report illustrates a sHLH case caused by Brucella melitensis infection. Here, we review the classification, clinical features, diagnostic methods, treatment regimens, differential diagnosis, and prognosis of HLH and brucellosis.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: FeiLiu reports financial support was provided by Natural Science Foundation Project of Chongqing. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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