Mechanotransducive surfaces for enhanced cell osteogenesis, a review.

Autor: Cuahtecontzi Delint R; Centre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address: Rosalia.CuahtecontziDelint@glasgow.ac.uk., Jaffery H; Centre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Ishak MI; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK., Nobbs AH; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK., Su B; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK., Dalby MJ; Centre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Jazyk: angličtina
Zdroj: Biomaterials advances [Biomater Adv] 2024 Jun; Vol. 160, pp. 213861. Date of Electronic Publication: 2024 Apr 15.
DOI: 10.1016/j.bioadv.2024.213861
Abstrakt: Novel strategies employing mechano-transducing materials eliciting biological outcomes have recently emerged for controlling cellular behaviour. Targeted cellular responses are achieved by manipulating physical, chemical, or biochemical modification of material properties. Advances in techniques such as nanopatterning, chemical modification, biochemical molecule embedding, force-tuneable materials, and artificial extracellular matrices are helping understand cellular mechanotransduction. Collectively, these strategies manipulate cellular sensing and regulate signalling cascades including focal adhesions, YAP-TAZ transcription factors, and multiple osteogenic pathways. In this minireview, we are providing a summary of the influence that these materials, particularly titanium-based orthopaedic materials, have on cells. We also highlight recent complementary methodological developments including, but not limited to, the use of metabolomics for identification of active biomolecules that drive cellular differentiation.
Competing Interests: Declaration of competing interest All authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this review article “Mechanotransducive Surfaces for Enhanced Cell Osteogenesis, a review”.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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