Regenerative Medicine in Gynecology.
| Autor: | Balough JL; Department of Obstetrics, Gynecology, and Reproductive Science, the Department of Bioengineering, Swanson School of Engineering, and The McGowan Institute of Regenerative Medicine, University of Pittsburgh, Magee-Women's Research Institute, University of Pittsburgh Medical Center, and the Division of Urogynecology and Reconstructive Pelvic Surgery, University of Pittsburgh Medical Center Magee-Women's Hospital, Pittsburgh, Pennsylvania., Moalli P |
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| Jazyk: | angličtina |
| Zdroj: | Obstetrics and gynecology [Obstet Gynecol] 2024 Jun 01; Vol. 143 (6), pp. 767-773. Date of Electronic Publication: 2024 Apr 25. |
| DOI: | 10.1097/AOG.0000000000005590 |
| Abstrakt: | The female reproductive tract undergoes dynamic changes across the life span. Congenital abnormalities, life events, and medical interventions can negatively affect the structure and function of reproductive tract organs, resulting in lifelong sequelae. The objective of regenerative gynecology is to discover and promote endogenous mechanisms by which a healthy tissue maintains overall tissue integrity after injury, after disease, or with age. In this review, we discuss some of the key state-of-the-art cell-based and scaffolding therapies that have been applied to regenerate gynecologic tissues and organs primarily in animal and tissue culture models. We further discuss the limitations of current technologies, problems of implementation and scalability, and future outlook of the field. Competing Interests: Financial Disclosure The authors did not report any potential conflicts of interest. (Copyright © 2024 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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