The potential importance of the built-environment microbiome and its impact on human health.

Autor:	Bosch TCG; Zoological Institute, University of Kiel, Kiel 24118, Germany.; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada., Wigley M; Graduate School of Architecture, Planning and Preservation, Columbia University, New York, NY 10027., Colomina B; School of Architecture, Princeton University, Princeton, NJ 08544., Bohannan B; The Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403-5289., Meggers F; Princeton University School of Architecture & Andlinger Center for Energy and the Environment, Princeton, NJ 08540., Amato KR; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Anthropology, Northwestern University, Evanston, IL 60208., Azad MB; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3E 0Z3, Canada.; Department of Community Health Sciences, University of Manitoba, Winnipeg, MB R3E 3P5, Canada., Blaser MJ; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Children's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada.; Center for Advanced Biotechnology and Medicine at Rutgers Biomedical and Health Sciences, Rutgers University, Piscataway, NJ 08854-8021., Brown K; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Program in Science, Technology and Society, Massachusetts Institute of Technology, Cambridge, MA 02139., Dominguez-Bello MG; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901.; Department of Anthropology, Rutgers University, New Brunswick, NJ 08901., Ehrlich SD; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Institute of Neurology, University College London, London WC1N 3RX, United Kingdom., Elinav E; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Systems Immunology Department, Weizmann Institute of Science, Rehovot 761000, Israel.; Division of Microbiome & Cancer, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany., Finlay BB; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Geddie K; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Medical and Related Sciences Centre, The Canadian Institute for Advanced Research, Toronto, ON M5G 1L7, Canada., Geva-Zatorsky N; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Technion Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3525433, Israel.; Department of Cell Biology and Cancer Science, Technion-Israel Institute of Technology, Haifa 3525433, Israel., Giles-Vernick T; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Anthropology & Ecology of Disease Emergence, Institut Pasteur, Université Paris Cité, Paris 75015, France., Gros P; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada., Guillemin K; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403., Haraoui LP; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Canada J1E 4K8., Johnson E; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; College of Human Ecology, Cornell University, Ithaka NY 14853., Keck F; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Laboratoire d'Anthropologie Sociale, Collège de France, Paris 75005, France., Lorimer J; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; School of Geography and the Environment, University of Oxford, OX1 3QY, United Kingdom., McFall-Ngai MJ; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Division of Biology and Biological Engineering, Caltech, Pasadena, CA 91125., Nichter M; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; School of Anthropology, University of Arizona, Tucson, AZ 85721., Pettersson S; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Nanyang Technological University, Singapore 637715, Singapore., Poinar H; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Anthropology, McMaster University, Hamilton, ON L8S 4M4, Canada., Rees T; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; LIMN, Berkeley, CA 94708., Tropini C; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Microbiology and Immunology and School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Undurraga EA; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Escuela de Gobierno, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile., Zhao L; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901., Melby MK; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Anthropology, University of Delaware, Newark, DE 19716.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 14; Vol. 121 (20), pp. e2313971121. Date of Electronic Publication: 2024 Apr 25.
DOI:	10.1073/pnas.2313971121
Abstrakt:	There is increasing evidence that interactions between microbes and their hosts not only play a role in determining health and disease but also in emotions, thought, and behavior. Built environments greatly influence microbiome exposures because of their built-in highly specific microbiomes coproduced with myriad metaorganisms including humans, pets, plants, rodents, and insects. Seemingly static built structures host complex ecologies of microorganisms that are only starting to be mapped. These microbial ecologies of built environments are directly and interdependently affected by social, spatial, and technological norms. Advances in technology have made these organisms visible and forced the scientific community and architects to rethink gene-environment and microbe interactions respectively. Thus, built environment design must consider the microbiome, and research involving host-microbiome interaction must consider the built-environment. This paradigm shift becomes increasingly important as evidence grows that contemporary built environments are steadily reducing the microbial diversity essential for human health, well-being, and resilience while accelerating the symptoms of human chronic diseases including environmental allergies, and other more life-altering diseases. New models of design are required to balance maximizing exposure to microbial diversity while minimizing exposure to human-associated diseases. Sustained trans-disciplinary research across time (evolutionary, historical, and generational) and space (cultural and geographical) is needed to develop experimental design protocols that address multigenerational multispecies health and health equity in built environments. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu