Endometrial Cancer in a Family With RAD51D Gene Mutation.
| Autor: | Gilmore B; University of Vermont Medical Center, Burlington, VT., Logan L, McKinnon W, Everett E, Bryant BH |
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| Jazyk: | angličtina |
| Zdroj: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists [Int J Gynecol Pathol] 2024 Jul 01; Vol. 43 (4), pp. 349-353. Date of Electronic Publication: 2024 Mar 25. |
| DOI: | 10.1097/PGP.0000000000000981 |
| Abstrakt: | RAD51 complex plays an important role in homologous recombination deficiency and germline mutations have a well-documented association with breast and tubo-ovarian carcinoma, as well as serous-type endometrial carcinoma. We report a family of French Canadian ancestry with a germline mutation in RAD51D and two sisters presenting with endometrial carcinoma, endometrioid-type. The risk factors for endometrial adenocarcinoma, endometrioid-type are discussed in the context of the RAD51-associated carcinomas described to date. Competing Interests: The authors declare no conflict of interest. (Copyright © 2024 by the International Society of Gynecological Pathologists.) |
| Databáze: | MEDLINE |
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