Domain Swapping in Abiotic Foldamers.

Autor: Wang S; Department of Pharmacy, Ludwig-Maximilians-Universität in Munich, Butenandtstr. 5-13, 81377, München, Germany., Wicher B; Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806, Poznan, Poland., Douat C; Department of Pharmacy, Ludwig-Maximilians-Universität in Munich, Butenandtstr. 5-13, 81377, München, Germany., Maurizot V; CBMN (UMR 5248), Univ. Bordeaux, CNRS, Bordeaux INP, 2, Rue Robert Escarpit, 33600, Pessac, France., Huc I; Department of Pharmacy, Ludwig-Maximilians-Universität in Munich, Butenandtstr. 5-13, 81377, München, Germany.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Jul 08; Vol. 63 (28), pp. e202405091. Date of Electronic Publication: 2024 Jun 04.
DOI: 10.1002/anie.202405091
Abstrakt: Foldamer sequences that adopt tertiary helix-turn-helix folds mediated by helix-helix hydrogen bonding in organic solvents have been previously reported. In an attempt to create genuine abiotic quaternary structures, i.e. assemblies of tertiary structures, new sequences were prepared that possess additional hydrogen bond donors at positions that may promote an association between the tertiary folds. However, a solid state structure and extensive solution state investigations by Nuclear Magnetic Resonance (NMR) and Circular Dichroism (CD) show that, instead of forming a quaternary structure, the tertiary folds assemble into stable domain-swapped dimer motifs. Domain swapping entails a complete reorganization of the arrays of hydrogen bonds and changes in relative helix orientation and handedness that can all be rationalized.
(© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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