Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/SUO Guideline (2017; Amended 2020, 2024).

Autor:	Holzbeierlein J; Department of Urology, University of Kansas Cancer Center, Kansas City, Kansas., Bixler BR; American Urological Association, Linthicum, Maryland., Buckley DI; Pacific Northwest Evidence-based Practice Center, Oregon Health & Science University, Portland, Oregon., Chang SS; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee., Holmes RS; Pacific Northwest Evidence-based Practice Center, Oregon Health & Science University, Portland, Oregon., James AC; Department of Urology, Texas Urology Group, San Antonio, Texas., Kirkby E; American Urological Association, Linthicum, Maryland., McKiernan JM; Department of Urology, Columbia University, New York, New York., Schuckman A; Department of Urology, University of Southern California, Los Angeles, California.
Jazyk:	angličtina
Zdroj:	The Journal of urology [J Urol] 2024 Jul; Vol. 212 (1), pp. 3-10. Date of Electronic Publication: 2024 Apr 25.
DOI:	10.1097/JU.0000000000003981
Abstrakt:	Purpose: Although representing approximately 25% of patients diagnosed with bladder cancer, muscle-invasive bladder cancer (MIBC) carries a significant risk of death that has not significantly changed in decades. Increasingly, clinicians and patients recognize the importance of multidisciplinary collaborative efforts that take into account survival and quality of life concerns. This guideline provides a risk-stratified, clinical framework for the management of muscle-invasive urothelial bladder cancer. Methodology/methods: In 2024, the MIBC guideline was updated through the AUA amendment process in which newly published literature is reviewed and integrated into previously published guidelines in an effort to maintain currency. The amendment allowed for the incorporation of additional literature released since the previous 2020 amendment. The updated search gathered literature from May 2020 to November 2023. This review identified 3739 abstracts, of which 46 met inclusion criteria.When sufficient evidence existed, the body of evidence was assigned a strength rating of A (high), B (moderate), or C (low) for support of Strong, Moderate, or Conditional Recommendations. In the absence of sufficient evidence, additional information is provided as Clinical Principles and Expert Opinions. Results: Updates were made regarding neoadjuvant/adjuvant chemotherapy, radical cystectomy, pelvic lymphadenectomy, multi-modal bladder preserving therapy, and future directions. Further revisions were made to the methodology and reference sections as appropriate. Conclusions: This guideline seeks to improve clinicians' ability to evaluate and treat patients with MIBC based on currently available evidence. Future studies will be essential to further support or refine these statements to improve patient care.
Databáze:	MEDLINE
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