The associations between daily reports of loneliness and psychotic experiences in the early risk stages for psychosis.

Autor: Raposo de Almeida E; Interdisciplinary Center of Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands.; Institute & Department of Psychiatry (LIM-23), Hospital das Clinicas, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., van der Tuin S; Interdisciplinary Center of Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands., Muller MK; Interdisciplinary Center of Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands., van den Berg D; Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands.; Department of Clinical Psychology, VU University and Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Wang YP; Institute & Department of Psychiatry (LIM-23), Hospital das Clinicas, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Veling W; University Center of Psychiatry, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Booij SH; Interdisciplinary Center of Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands., Wigman JTW; Interdisciplinary Center of Psychopathology and Emotion Regulation, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands.
Jazyk: angličtina
Zdroj: Early intervention in psychiatry [Early Interv Psychiatry] 2024 Nov; Vol. 18 (11), pp. 930-942. Date of Electronic Publication: 2024 Apr 25.
DOI: 10.1111/eip.13537
Abstrakt: Aim: Bi-directional associations between loneliness and psychotic experiences (PEs) have been reported, but the mechanisms underlying these associations are unknown. This study aims to explore associations between daily reports of loneliness and PEs, and test differences in this association across young adult individuals at different levels of risk for psychosis.
Methods: We analysed 90-day diary data on loneliness and PEs from N = 96 participants (mean age 24.7, range 18-35, 77% female) divided into 4 subgroups, each indexing increased levels of risk for psychosis according to the clinical staging model: 'psychometric' (n = 25), 'low' (n = 27), 'mild' (n = 24), and 'ultra-high'(n = 20) risk. Multilevel vector autoregressive models examined within-day (contemporaneous) and between-day (temporal) associations between loneliness and PEs for the total sample. Next, these associations were compared across subgroups.
Results: Loneliness and PEs were significantly associated contemporaneously (partial correlation B = 0.14) but not temporally. Subgroup membership moderated both contemporaneous and temporal associations. The contemporaneous association between loneliness and PEs was stronger in the low-risk subgroup compared to the mild-risk (B = -0.35, p < .01) and ultra-high-risk (B = -0.36, p < .01) subgroups. The temporal association between loneliness on the previous day and PEs on the current day was stronger in mild-risk subgroup compared to the ultra-high-risk subgroup (B = -0.03, p = .03). After adjusting for multiple testing, only the contemporaneous-but not the temporal-associations remained statistically significant.
Conclusions: Loneliness is associated with PEs in individuals at risk for psychosis, particularly in those with low to mild symptoms. Our findings tentatively suggest that especially individuals with low expressions of PEs may be more sensitive to social context, but future studies are needed to replicate and further unravel the potentially stage-specific interplay between social context and PEs.
(© 2024 The Authors. Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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