Hepatitis B virus genotypes in precision medicine of hepatitis B-related hepatocellular carcinoma: Where we are now.

Autor:	Sukowati CHC; Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Jakarta 10340, Indonesia.; Liver Cancer Unit, Fondazione Italiana Fegato ONLUS, Trieste 34149, Italy. caecilia.sukowati@fegato.it., Jayanti S; Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Jakarta 10340, Indonesia., Turyadi T; Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Jakarta 10340, Indonesia., Muljono DH; Faculty of Medicine, Hasanuddin University, Makassar 90245, South Sulawesi, Indonesia.; Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia., Tiribelli C; Liver Cancer Unit, Fondazione Italiana Fegato ONLUS, Trieste 34149, Italy.
Jazyk:	angličtina
Zdroj:	World journal of gastrointestinal oncology [World J Gastrointest Oncol] 2024 Apr 15; Vol. 16 (4), pp. 1097-1103.
DOI:	10.4251/wjgo.v16.i4.1097
Abstrakt:	Hepatitis B virus (HBV) infection is a major player in chronic hepatitis B that may lead to the development of hepatocellular carcinoma (HCC). HBV genetics are diverse where it is classified into at least 9 genotypes (A to I) and 1 putative genotype (J), each with specific geographical distribution and possible different clinical outcomes in the patient. This diversity may be associated with the precision medicine for HBV-related HCC and the success of therapeutical approaches against HCC, related to different pathogenicity of the virus and host response. This Editorial discusses recent updates on whether the classification of HBV genetic diversity is still valid in terms of viral oncogenicity to the HCC and its precision medicine, in addition to the recent advances in cellular and molecular biology technologies. Competing Interests: Conflict-of-interest statement: All authors declare no conflict-of-interest. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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