Going beyond summed stress scores: Correlating global and territorial coronary flow reserve by single photon emission tomography with routine myocardial perfusion imaging.

Autor:	Chng AC; National Heart Centre Singapore, Singapore., Keng BM; National Heart Centre Singapore, Singapore., Teng XF; National Heart Centre Singapore, Singapore., Aik KW; National Heart Centre Singapore, Singapore., Azman MK; National Heart Centre Singapore, Singapore., Natividad LR; National Heart Centre Singapore, Singapore., Chong CS; National Heart Centre Singapore, Singapore., Neela PN; National Heart Centre Singapore, Singapore., Tan RS; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore., Baskaran L; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore., Chua TS; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore., Keng FY; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore., Koh AS; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Apr 14; Vol. 10 (8), pp. e29629. Date of Electronic Publication: 2024 Apr 14 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e29629
Abstrakt:	A Background: Technological advancement in the recent years has enabled the application of single photon emission tomography (SPECT) to evaluate myocardial blood flow (MBF). This method offers increased sensitivity in the assessment of coronary health, quantifiable through non-invasive imaging beyond the more conventional methods such as with myocardial perfusion imaging (MPI). B Aims: To correlate MBF, derived by dynamic SPECT, both global and by coronary territories to the summed stress scores (SSS) on conventional MPI. C Methods: Images obtained from dipyridamole-gated SPECT MPI stress and rest studies performed on recruited subjects were examined. We calculated the global and regional coronary flow reserve (CFR) via a standard software package, taken as the ratio of stress MBF to rest MBF, using CFR<2.5 as the cut off. D Results: Amongst the 90 recruited subjects (mean age 67 ± 8 years; of which 76% were males), 49% had MPI within normal limits (summed stress score (SSS) 0-3; Left ventricular ejection fraction (LVEF) > 50%). We observed a progressive reduction in global and regional CFR across the normal SSS category to that of severely abnormal (SSS >13). Reduced global CFR with correspondent lower CFR across the regional arteries were detected in scans within normal limits of MPI scans in subjects who were older (69 ± 7 vs. 62 ± 9 years, p = 0.034). Decreasing CFR was significantly associated with increasing age across the regional arteries. E Conclusion: In our study we depict the global and regional MBF values obtained via SPECT MPI in correlation to the respective SSS categories. Our data proposes that dynamic SPECT has a part in refining cardiac risk stratification, particularly in the older adult population, who are at greater risk. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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