Lateral frontoparietal functional connectivity based on individual sulcal morphology.

Autor:	Häkkinen S; Department of Psychology, University of California, Berkeley, Berkeley, CA, 94720 USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720 USA., Voorhies WI; Department of Psychology, University of California, Berkeley, Berkeley, CA, 94720 USA., Willbrand EH; Department of Psychology, University of California, Berkeley, Berkeley, CA, 94720 USA.; Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726 USA., Tsai YH; Department of Psychology, University of California, Berkeley, Berkeley, CA, 94720 USA.; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA., Gagnant T; Department of Psychology, University of California, Berkeley, Berkeley, CA, 94720 USA.; Medical Science Faculty, University of Bordeaux, Bordeaux, France., Yao JK; Department of Psychology, Stanford University., Weiner KS; Department of Psychology, University of California, Berkeley, Berkeley, CA, 94720 USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720 USA., Bunge SA; Department of Psychology, University of California, Berkeley, Berkeley, CA, 94720 USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720 USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 18. Date of Electronic Publication: 2024 Apr 18.
DOI:	10.1101/2024.04.18.590165
Abstrakt:	A salient neuroanatomical feature of the human brain is its pronounced cortical folding, and there is mounting evidence that sulcal morphology is relevant to functional brain architecture and cognition. Recent studies have emphasized putative tertiary sulci (pTS): small, shallow, late-developing, and evolutionarily new sulci that have been posited to serve as functional landmarks in association cortices. A fruitful approach to characterizing brain architecture has been to delineate regions based on transitions in fMRI-based functional connectivity profiles; however, exact regional boundaries can change depending on the data used to generate the parcellation. As sulci are fixed neuroanatomical structures, here, we propose to anchor functional connectivity to individual-level sulcal anatomy. We characterized fine-grained patterns of functional connectivity across 42 sulci in lateral prefrontal (LPFC) and lateral parietal cortices (LPC) in a pediatric sample (N = 43; 20 female; ages 7-18). Further, we test for relationships between pTS morphology and functional network architecture, focusing on depth as a defining characteristic of these shallow sulci, and one that has been linked to variability in cognition. We find that 1) individual sulci have distinct patterns of connectivity, but nonetheless cluster together into groups with similar patterns - in some cases with distant rather than neighboring sulci, 2) there is moderate agreement in cluster assignments at the group and individual levels, underscoring the need for individual-level analyses, and 3) across individuals, greater depth was associated with higher network centrality for several pTS. These results highlight the importance of considering individual sulcal morphology for understanding functional brain organization. Significance Statement: A salient, and functionally relevant, feature of the human brain is its pronounced cortical folding. However, the links between sulcal anatomy and brain function are still poorly understood - particularly for small, shallow, individually variable sulci in association cortices. Here, we explore functional connectivity among individually defined sulci in lateral prefrontal and parietal regions. We find that individual sulci have distinct patterns of connectivity but nonetheless cluster together into groups with similar connectivity - in some cases spanning lateral prefrontal and parietal sulci. We further show that the network centrality of specific sulci is positively associated with their depth, thereby helping to bridge the gap between individual differences in brain anatomy and functional networks leveraging the sulcal anatomy of the individual. Competing Interests: Conflict of interest statement: The authors declare no competing financial interests.
Databáze:	MEDLINE
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