Clinical, pathologic and molecular findings in 2 Rottweiler littermates with appendicular osteosarcoma.

Autor:	Silver KI; National Cancer Institute, NIH., Mannheimer JD; National Cancer Institute, NIH., Saba C; University of Georgia., Hendricks WPD; Vidium Animal Health, A Subsidiary of The Translational Genomics Research Institute (TGen)., Wang G; Vidium Animal Health, A Subsidiary of The Translational Genomics Research Institute (TGen)., Day K; Vidium Animal Health, A Subsidiary of The Translational Genomics Research Institute (TGen)., Warrier M; Vidium Animal Health, A Subsidiary of The Translational Genomics Research Institute (TGen)., Beck JA; National Cancer Institute, NIH., Mazcko C; National Cancer Institute, NIH., LeBlanc AK; National Cancer Institute, NIH.
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2024 Apr 11. Date of Electronic Publication: 2024 Apr 11.
DOI:	10.21203/rs.3.rs-4223759/v1
Abstrakt:	Appendicular osteosarcoma was diagnosed and treated in a pair of littermate Rottweiler dogs, resulting in distinctly different clinical outcomes despite similar therapy within the context of a prospective, randomized clinical trial (NCI-COTC021/022). Histopathology, immunohistochemistry, mRNA sequencing, and targeted DNA hotspot sequencing techniques were applied to both dogs' tumors to define factors that could underpin their differential response to treatment. We describe the comparison of their clinical, histologic and molecular features, as well as those from a companion cohort of Rottweiler dogs, providing new insight into potential prognostic biomarkers for canine osteosarcoma. Competing Interests: Competing interests: AKL and JAB are members of the Editorial board for BMC Veterinary Oncology.
Databáze:	MEDLINE
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