Enhancing Prosthetic Vision by Upgrade of a Subretinal Photovoltaic Implant in situ.

Autor:	Bhuckory MB; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94303, USA.; Department of Ophthalmology, Stanford University, Stanford, CA, USA., Monkongpitukkul N; Department of Ophthalmology, Stanford University, Stanford, CA, USA.; Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Thailand., Shin A; Department of Material Science, Stanford University, Stanford, CA, USA., Goldstein AK; Department of Electrical Engineering, Stanford University, Stanford, CA, USA., Jensen N; Department of Electrical Engineering, Stanford University, Stanford, CA, USA., Shah SV; Department of Ophthalmology, Stanford University, Stanford, CA, USA., Pham-Howard D; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94303, USA.; Department of Ophthalmology, Stanford University, Stanford, CA, USA., Butt E; Department of Physics, University of Strathclyde, Glasgow, Scotland, UK., Dalal R; Department of Ophthalmology, Stanford University, Stanford, CA, USA., Galambos L; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94303, USA., Mathieson K; Department of Physics, University of Strathclyde, Glasgow, Scotland, UK., Kamins T; Department of Electrical Engineering, Stanford University, Stanford, CA, USA., Palanker D; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94303, USA.; Department of Ophthalmology, Stanford University, Stanford, CA, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 19. Date of Electronic Publication: 2024 Apr 19.
DOI:	10.1101/2024.04.15.589465
Abstrakt:	In patients with atrophic age-related macular degeneration, subretinal photovoltaic implant (PRIMA) provided visual acuity up to 20/440, matching its 100μm pixels size. Next-generation implants with smaller pixels should significantly improve the acuity. This study in rats evaluates removal of a subretinal implant, replacement with a newer device, and the resulting grating acuity in-vivo. Six weeks after the initial implantation with planar and 3-dimensional devices, the retina was re-detached, and the devices were successfully removed. Histology demonstrated a preserved inner nuclear layer. Re-implantation of new devices into the same location demonstrated retinal re-attachment to a new implant. New devices with 22μm pixels increased the grating acuity from the 100μm capability of PRIMA implants to 28μm, reaching the limit of natural resolution in rats. Reimplanted devices exhibited the same stimulation threshold as for the first implantation of the same implants in a control group. This study demonstrates the feasibility of safely upgrading the subretinal photovoltaic implants to improve prosthetic visual acuity. Competing Interests: Competing interests: Ted Kamins: Consultant (Pixium Vision) Daniel Palanker: Patent, Consultant (Pixium Vision) Other authors have no other competing interests to declare.
Databáze:	MEDLINE
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