Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations.

Autor:	Reddy JS; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Heath L; Sage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121., Vander Linden A; Sage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121., Allen M; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., de Paiva Lopes K; Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612., Seifar F; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Wang E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029., Ma Y; Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032., Poehlman WL; Sage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121., Quicksall ZS; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Runnels A; New York Genome Center, 101 6th Ave, New York, NY 10013., Wang Y; Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612., Duong DM; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Yin L; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Xu K; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Modeste ES; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Shantaraman A; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Dammer EB; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Ping L; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Oatman SR; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Scanlan J; Sage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121., Ho C; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Carrasquillo MM; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Atik M; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Yepez G; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Mitchell AO; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Nguyen TT; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Chen X; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Marquez DX; Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612.; University of Illinois Chicago, 1200 West Harrison St., Chicago, Illinois 60607., Reddy H; Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032., Xiao H; Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032., Seshadri S; The Glen Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas, 8300 Floyd Curl Drive, San Antonio TX 78229., Mayeux R; Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032., Prokop S; University of Florida, Gainesville, FL 32611., Lee EB; Center for Neurodegenerative Disease Brain Bank at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104-2676., Serrano GE; Banner Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351., Beach TG; Banner Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351., Teich AF; Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032., Haroutunian V; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029., Fox EJ; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Gearing M; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Wingo A; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Wingo T; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Lah JJ; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Levey AI; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Dickson DW; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612., De Jager P; Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032., Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029., Bennett D; Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612., Seyfried NT; Emory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322., Greenwood AK; Sage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121., Ertekin-Taner N; Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 20. Date of Electronic Publication: 2024 Apr 20.
DOI:	10.1101/2024.04.16.589592
Abstrakt:	Introduction: Multi-omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked African Americans (AA) and Latin Americans (LA), who are disproportionately affected by AD. Methods: To bridge this gap, Accelerating Medicines Partnership in AD (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors. Results: We generated multi-omics data and curated and harmonized phenotypic data from AA (n=306), LA (n=326), or AA and LA (n=4) brain donors plus Non-Hispanic White (n=252) and other (n=20) ethnic groups, to establish a foundational dataset enriched for AA and LA participants. This study describes the data available to the research community, including transcriptome from three brain regions, whole genome sequence, and proteome measures. Discussion: Inclusion of traditionally underrepresented groups in multi-omics studies is essential to discover the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD. Competing Interests: Conflict of interest statement The authors declare no conflicts of interest. Author disclosures are available in the supporting information.
Databáze:	MEDLINE
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