A case of diffuse large B-cell lymphoma with decompensated alcohol-related liver cirrhosis treated successfully by chemoimmunotherapy.

Autor: Li Y; Department of Haematology Hebei General Hospital Shijiazhuang Hebei People's Republic of China., Kong LZ; Department of Haematology Hebei General Hospital Shijiazhuang Hebei People's Republic of China.; Department of Graduate School Hebei North University Zhangjiakou Hebei People's Republic of China.
Jazyk: angličtina
Zdroj: Clinical case reports [Clin Case Rep] 2024 Apr 23; Vol. 12 (4), pp. e8820. Date of Electronic Publication: 2024 Apr 23 (Print Publication: 2024).
DOI: 10.1002/ccr3.8820
Abstrakt: Key Clinical Message: This report describes a case of diffuse large B-cell lymphoma with MYD88 L265P and KM2DT mutation and decompensated alcohol-related liver cirrhosis. And the treatment is successful in this patient, who had multiple complications and poor prognostic factors.
Abstract: This report describes a case of diffuse large B-cell lymphoma with MYD88 L265P and KM2DT mutation and decompensated alcohol-related liver cirrhosis. The lymphoma showed a complete response with no MYD88 L265P mutation after four courses of combination chemotherapy. Lymphoma is one of the most common malignant tumors, but cases of DLBCL with cirrhosis are much rarer especially with alcohol-related cirrhosis. And we reviewed the relevant mechanisms. Although we did not find a definite association between the pathogenesis of the patient's alcohol-related cirrhosis and that of diffuse large B-cell lymphoma, the treatment is successful in this patient, who had multiple complications and poor prognostic factors.
Competing Interests: The authors declare that they have no competing interests.
(© 2024 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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