Association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography.

Autor: ShaMa A; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China., Xu C; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China., Huang Y; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China., Ma C; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China., Hu J; Department of Neurology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China., Li Z; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.; Chongqing Key Laboratory for Hypertension Research, Chongqing Cardiovascular Clinical Research Center, Chongqing Institute of Cardiology, Chongqing, China., Zeng C; Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China. chunyuzeng01@163.com.; Chongqing Key Laboratory for Hypertension Research, Chongqing Cardiovascular Clinical Research Center, Chongqing Institute of Cardiology, Chongqing, China. chunyuzeng01@163.com.; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China. chunyuzeng01@163.com.; Heart Center of Fujian Province, Union Hospital, Fujian Medical University, Fuzhou, China. chunyuzeng01@163.com.; Department of Cardiology, Chongqing General Hospital, Chongqing, China. chunyuzeng01@163.com.; Cardiovascular Research Center of Chongqing College, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Chongqing, China. chunyuzeng01@163.com.
Jazyk: angličtina
Zdroj: Herz [Herz] 2024 Oct; Vol. 49 (5), pp. 378-384. Date of Electronic Publication: 2024 Apr 24.
DOI: 10.1007/s00059-024-05247-0
Abstrakt: Objective: Many previous studies reported the relationship between lipoprotein(a) and cardiovascular disease, but the conclusions were controversial. The aim of our study was to retrospectively investigate the association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography.
Methods: We collected and compared clinical information of patients hospitalized for coronary angiography. Multivariable hierarchical logistic regression was used to evaluate the association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography.
Results: There were no significant differences in gender, hypertension, APOA1, smoking, hyperuricemia, obesity, acute myocardial infarction (AMI), cardiac insufficiency, family history of diabetes, or family history of hyperlipidemia among the four groups of lipoprotein(a). Elevated lipoprotein(a) does not increase the risk of hypertriglyceridemia, while elevated lipoprotein(a) increases the risk of high total cholesterol and high low-density lipoprotein cholesterol (LDL-c). Elevated lipoprotein(a) increases the risk of diabetes and premature coronary artery disease (CAD). Elevated lipoprotein(a) increases the incidence of CAD, multivessel lesions, and percutaneous coronary intervention (PCI). Multivariate logistic regression analysis further showed that elevated lipoprotein(a) increases the incidence of high total cholesterol, high LDL‑c, diabetes, CAD, premature CAD, multivessel lesions, and PCI.
Conclusion: The findings indicated that elevated lipoprotein(a) had no obvious relationship with hypertension and obesity. Elevated lipoprotein(a) increases the risk of high total cholesterol, high LDL‑c, and premature CAD, and increases the occurrence and severity of coronary heart disease.
(© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
Databáze: MEDLINE
Externí odkaz: