Impact of methimazole-induced hypothyroidism on postnatal swine.

Autor: Fazioli JC; Department of Animal Science, Purdue University, West Lafayette, Indiana, USA., Mulligan MK; Department of Animal Science, Purdue University, West Lafayette, Indiana, USA., Ison EK; Department of Animal Science, Purdue University, West Lafayette, Indiana, USA., Pasternak JA; Department of Animal Science, Purdue University, West Lafayette, Indiana, USA.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2024 Apr; Vol. 12 (8), pp. e16007.
DOI: 10.14814/phy2.16007
Abstrakt: Thyroid hormones regulate metabolic rate, nutrient utilization, growth, and development. Swine are susceptible to thyroid suppression in response to disease or environmental conditions, but the physiological impact of such disruption has not been established. The objective of this study was to evaluate the impact of hypothyroidism induced with the antithyroid medication methimazole (MMI). 10 mg/kg MMI significantly decreased circulating triiodothyronine (T3) for the duration of treatment but had only a transient effect on circulating thyroxine (T4). Thyroid tissue weight was significantly increased by more than 3.5-fold in response to MMI treatment. Histologically, the eosinophilic colloid was largely absent from the thyroid follicle which displayed a disorganized columnar epithelium consistent with goiter. MMI induced hypothyroidism has no effect on growth rate over 28 days. Hepatic expression of genes associated with thyroid metabolism (DIO1, DIO2, and DIO3), lipid utilization (CD36, FASN, and ACACA), apoptosis (TP53, PERP, SIVA1, and SFN) and proliferation (CDK1, CDK2, CDK4, and CDKN1A) were unaffected by treatment. Collectively these results demonstrate that MMI induces mild systemic hypothyroidism and pronounced goiter, indicating a strong homeostatic central regulation within the hypothalamic pituitary thyroid axis. This combined with limited peripheral effects, indicates resilience to hypothyroidism in modern swine.
(© 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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