Iron biology.
| Autor: | Del Vecchio L; Department of Nephrology and Dialysis, Sant'Anna Hospital, ASST Lariana, Como 22100, Italy., Girelli D; Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy., Vinchi F; Iron Research Laboratory, Lindsley Kimball Research Institute, New York Blood Center, NY, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, NY, USA., Cozzolino M; Renal Division, Department of Health Sciences, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy., Elliott S; Elliott Consulting, Thousand Oaks, CA, USA., Mark PB; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Valenti L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.; Precision Medicine, Biological Resource Center Unit, Department of Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Qian C; School of Biomedical Sciences and Gerald Choa Neuroscience Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong., Guo Q; School of Medicine, Shanghai University, Shanghai, China., Qian ZM; Institute of Translational & Precision Medicine, Nantong University, Nantong, JS, China.; Laboratory of Neuropharmacology, Fudan University School of Pharmacy, Shanghai; and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China., Ciceri P; Renal Division, Department of Health Sciences, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy., Locatelli F; Department of Nephrology and Dialysis, (Past Director) Alessandro Manzoni Hospital, ASST Lecco, Lecco, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2024 Aug 30; Vol. 39 (9), pp. 1404-1415. |
| DOI: | 10.1093/ndt/gfae095 |
| Abstrakt: | Iron is a fundamental element for biological life, from bacteria to humans. Iron is essential for cell function and survival, energy production and metabolism, whereas increased levels cause oxidative stress. It is also a constituent of haemoglobin and thus it is necessary for oxygen transportation through the body. Given these multiple functions, the regulation of iron metabolism is complex and tight coupled with oxygen homeostasis at tissue and cellular levels, thanks to the interaction with the hypoxia inducible factor system. In patients with chronic kidney disease (CKD), iron deficiency significantly contributes to anaemia development. This frequently overlaps with chronic inflammation, causing iron- restricted erythropoiesis. To add further complexity, metabolic hyperferritinemia may, on one hand, increase the risk for CKD and, on the other, overlaps with functional iron deficiency. Excessive intracellular iron in certain cell types during CKD can also mediate cellular death (called ferroptosis), and contribute to the pathogenesis of kidney damage, atherosclerosis and vascular calcifications. This review is aimed at broadening the perspective of iron metabolism in the setting of CKD not just as a contributor to anaemia in CKD patients, but also as an important player with an impact on cell metabolism, renal fibrosis and the cardiovascular system. (© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.) |
| Databáze: | MEDLINE |
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