Enteropathy and intestinal malabsorption in patients treated with antihypertensive drugs. A retrospective cohort study .

Autor:	Lee SR; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Lee EG; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Cho YH; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Park EJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Lee YI; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Choi JI; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Kwon RJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Son SM; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Lee SY; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Yi YH; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Kim GL; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Kim YJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Lee JG; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Tak YJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Lee SH; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea., Ra YJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Department of Family Medicine (Y. J. Kim, J. G. Lee, Y. J. Tak, Y. H. Cho, Y. H. Yi, S.H. Lee); Department of Medical Education (S. Y. Lee), Pusan National University School of Medicine, and from the Integrated Research Institute for Natural Ingredients and Functional Foods (S. Y. Lee), Yangsan, South Korea.
Jazyk:	angličtina
Zdroj:	Saudi medical journal [Saudi Med J] 2024 Apr; Vol. 45 (4), pp. 437-441.
DOI:	10.15537/smj.2024.45.4.20230739
Abstrakt:	Objectives: To investigate differences in the incidence of enteropathy or intestinal malabsorption in patients taking angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitor (ACEI), calcium channel blocker (CCB), and beta blockers (BBs) at a single center in Korea. Methods: In this retrospective study, we utilized data from the Yangsan electronic medical records to identify 129,169 patients. These individuals were prescribed olmesartan, other ARBs, ACEI, CCB, and BBs between November 2008 and February 2021. Results: Of the 44,775 patients, 51 (0.11%) were observed to have enteropathy or intestinal malabsorption. Compared with the ACEI group, the adjusted odds ratios (ORs) for enteropathy and intestinal malabsorption were OR=1.313 (95% confidence interval [CI]: [0.188-6.798], p =0.893) for olmesartan, OR=0.915 (95% CI: [0.525-1.595], p =0.754) for the other ARBs, OR=0.928 (95% CI: [0.200-4.307]; p =0.924) for the CCB, and OR=0.663 (95% CI: [0.151-2.906]; p =0.586) for the BBs group. These findings were adjusted for factors such as age, gender, duration of antihypertensive medication, and comorbidities. Conclusion: In a retrospective cohort study of patients on antihypertensive medications, no significant difference was found in the incidence of enteropathy or intestinal malabsorption when ACEI was compared to olmesartan, other ARBs, CCB, and BBs. (Copyright: © Saudi Medical Journal.)
Databáze:	MEDLINE
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